hCA/VEGFR-2-IN-2
hCA/VEGFR-2-IN-2 (compound 8g) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-2 inhibits VEGFR-2 (IC50=204 nM) and has high binding activity to hCAs, with Kis of 3.6 nM (hCA IX), 16.1 nM (hCA II), 16.7 nM (hCA XII), and 75.3 nM (hCA I), respectively. hCA/VEGFR-2-IN-2 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2971782-66-6
- Formula: C23H26N6O5S
- Molecular Weight:498.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All VEGFR Isoforms
More
Biological Activity
IC50: 204 nM (VEGFR-2), 3.6 nM (hCA IX), 16.1 nM (hCA II), 16.7 nM (hCA XII), 75.3 nM (hCA I)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
9.997 μM
Compound: 8g
|
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
|
[PMID: 37556946] |
| MDA-MB-231 | IC50 |
4.083 μM
Compound: 8g
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
|
[PMID: 37556946] |
Chemical Information
-
CAS No. 2971782-66-6
-
Molecular Weight 498.55
-
Formula C23H26N6O5S
-
SMILES
CC(N1CC(C(N/N=C2C(NC3=C\2C=CC=C3)=O)=O)CCC1)C(NC4=CC=C(S(=O)(N)=O)C=C4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCA/VEGFR-2-IN-2 Related Classifications
HY-155758 Related Classifications
Powered by Bioz