1. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  2. VEGFR Carbonic Anhydrase
  3. hCA/VEGFR-2-IN-4

hCA/VEGFR-2-IN-4 (compound 15b) is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 (IC50=0.811 μM) and has high binding activity to hCAs, with Ki of 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I), respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells.

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hCA/VEGFR-2-IN-4 Chemical Structure

hCA/VEGFR-2-IN-4 Chemical Structure

CAS No. : 2971782-83-7

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Description

hCA/VEGFR-2-IN-4 (compound 15b) is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 (IC50=0.811 μM) and has high binding activity to hCAs, with Ki of 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I), respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells[1].

IC50 & Target

IC50: 0.811 μM (VEGFR-2), 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I)[1]

In Vivo

hCA/VEGFR-2-IN-4 (compound 15b)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

502.52

Formula

C22H23FN6O5S

CAS No.
SMILES

O=C(CN1CCC(CC1)C(N/N=C2C(NC3=C\2C=C(C=C3)F)=O)=O)NC4=CC=C(C=C4)S(=O)(N)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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hCA/VEGFR-2-IN-4
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HY-155763
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