hCA/VEGFR-2-IN-4
hCA/VEGFR-2-IN-4 (compound 15b) is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 (IC50=0.811 μM) and has high binding activity to hCAs, with Ki of 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I), respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2971782-83-7
- Formula: C22H23FN6O5S
- Molecular Weight:502.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.811 μM (VEGFR-2), 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
29.292 μM
Compound: 15b
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
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[PMID: 37556946] |
| MDA-MB-231 | IC50 |
18.853 μM
Compound: 15b
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT reagent based ELISA
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[PMID: 37556946] |
Chemical Information
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CAS No. 2971782-83-7
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Molecular Weight 502.52
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Formula C22H23FN6O5S
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SMILES
O=C(CN1CCC(CC1)C(N/N=C2C(NC3=C\2C=C(C=C3)F)=O)=O)NC4=CC=C(C=C4)S(=O)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCA/VEGFR-2-IN-4 Related Classifications
HY-155763 Related Classifications
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