HIF-PHD-IN-1
Based on 1 Customer Validation
HIF-PHD-IN-1 is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), with an IC50 of 54 nM for hHIF-PHD2. HIF-PHD-IN-1 is promising therapeutic agents for renal anemia.
For research use only. We do not sell to patients.
- Purity: 98.84%
- CAS No.: 1567657-46-8
- Formula: C17H12Cl2N6O3
- Molecular Weight:419.22
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
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Immunology/Inflammation Compound Library
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Metabolism/Protease Compound Library
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Heterocyclic Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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Biological Activity
IC50: 54 nM (hHIF-PHD2)[1]
HIF-PHD-IN-1 (10 mg/kg; single p.o.) increases serum erythropoietin (EPO) concentration at 8 h after administration in SD rats[1].
HIF-PHD-IN-1 (1 mg/kg; p.o.) shows good bioavailability (F=77%) in male SD rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SD Rats excising five-sixths of their kidneys[1]
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Dosage:0.5, 1, 2 mg/kg
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Administration:P.o. once daily for 4 weeks
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Result:Improved blood hemoglobin levels starting at weeks 2 and 1 in the groups receiving 1 and 2 (mg/kg)/day, respectively.
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Animal Model:Male SD Rats[1]
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Dosage:1 mg/kg (Pharmacokinetic Analysis)
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Administration:Single p.o. or i.v.
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Result:Cmax=1839 ng/mL (p.o.); Cmax=12357ng/mL (i.v.); F=77%.
Chemical Information
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CAS No. 1567657-46-8
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Appearance Solid
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Molecular Weight 419.22
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Formula C17H12Cl2N6O3
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Color Off-white to light yellow
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SMILES
O=C(C1=CN(C2=NC3=C(N([C@H](C4=CC(Cl)=CC=C4Cl)C)N=C3)C(N2)=O)N=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (238.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3854 mL | 11.9269 mL | 23.8538 mL | 59.6346 mL |
| 5 mM | 0.4771 mL | 2.3854 mL | 4.7708 mL | 11.9269 mL | |
| 10 mM | 0.2385 mL | 1.1927 mL | 2.3854 mL | 5.9635 mL | |
| 15 mM | 0.1590 mL | 0.7951 mL | 1.5903 mL | 3.9756 mL | |
| 20 mM | 0.1193 mL | 0.5963 mL | 1.1927 mL | 2.9817 mL | |
| 25 mM | 0.0954 mL | 0.4771 mL | 0.9542 mL | 2.3854 mL | |
| 30 mM | 0.0795 mL | 0.3976 mL | 0.7951 mL | 1.9878 mL | |
| 40 mM | 0.0596 mL | 0.2982 mL | 0.5963 mL | 1.4909 mL | |
| 50 mM | 0.0477 mL | 0.2385 mL | 0.4771 mL | 1.1927 mL | |
| 60 mM | 0.0398 mL | 0.1988 mL | 0.3976 mL | 0.9939 mL | |
| 80 mM | 0.0298 mL | 0.1491 mL | 0.2982 mL | 0.7454 mL | |
| 100 mM | 0.0239 mL | 0.1193 mL | 0.2385 mL | 0.5963 mL |
HIF-PHD-IN-1 Related Classifications
HY-131346 Related Classifications
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