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Cangrelor

(Synonyms: AR-C69931MX)
4 Cited Publications
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Based on 4 publication(s) in Google Scholar

Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Cangrelor tetrasodium) that retains the same biological activity.

For research use only. We do not sell to patients.

  • CAS No.: 163706-06-7
  • Formula: C17H25Cl2F3N5O12P3S2
  • Molecular Weight:776.36
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Cangrelor Chemical Structure
    Cangrelor Chemical Structure
  • Experimental Validation Results for Cangrelor
  • Experimental Validation Results for Cangrelor
  • Experimental Validation Results for Cangrelor
  • Experimental Validation Results for Cangrelor
CAS No.: 163706-06-7
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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ELISACell Proliferation/Viability AssayWBIn Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • ELISA
  • WB

All P2Y Receptor Isoforms

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  • Cangrelor Chemical Structure
    Cangrelor Chemical Structure
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    Cangrelor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct 23:117451. [Abstract]

    Customer Validation
     Determination of Avibactam, Lopromide, Cangrelor tetrasodium, Protirelin, and Ioxilan IC50 values in Huh7 and Hep3B cells.

  • 1/16

    Cangrelor purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]

    Customer Validation
     Weight changes in mice infected with and treated with H1N1-UI182. The combined results of the two studies showed that treatment with glecaprevir, Cangrelor tetrasodium (Cangrelor), acarbose, and everolimus significantly slowed the rate of weight loss in virus-infected mice.

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    Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

    Customer Validation
     The EA. hy926 cells were pretreated with vehicle (M), OG-5 for 2 hours followed by stimulated with ADP for 4 hours, then the treated cells and supernatants were collected. The release of MCP-1 and VCAM-1 in supernatant were determined by ELISA kit and adhesion molecule ICAM-1 was determined in cell lysates. The results showed that treatment with OG-5 significantly inhibited the increase in ADP-induced MCP-1 and VCAM-1 production, showing a comparable effect with Cangrelor tetrasodium (0.5 µM) at the concentration of 0.5 mM.

  • 1/16

    Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

    Customer Validation
     Immunoblotting and densitometric analyses of p-VASP (Ser157). Platelets were preincubated with vehicle and different concentrations of OG-5 for 5 min at 37 ℃, in the presence or absence of the specific inhibitors and then stimulated with agonist. The reaction was stopped by addition of RIPA buffer immediately and the cell lysates were applied to immunoblot analysis with phospho-specific antibody. The results showed that Cangrelor tet (0.5 μM) attenuated the 2MeS-ADP-induced reduction in p-VASP(S157) levels.

  • Cangrelor