Cat. No.: HY-L017

Stem Cell Signaling Compound Library

86 Cited Publications

Customer Review

Based on 86 publication(s) in Google Scholar

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 2,849 compounds that can be used for stem cell regulatory and signaling pathway research.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (86)
Documentation
Composition

Description & Advantages

• A unique collection of 2,849 small molecule inhibitors with biological activity used for stem cell regulatory and signaling pathway research.

• Targets such as GSK-3, Hedgehog, Notch, JAK, ROCK, Wnt, γ-secretase, Casein Kinase, etc.

• A powerful tool for researching the mechanism behind stem cells, regenerative therapy, drug screening based on tumor stem cells, as well as other pharmaceutical and biological applications.

• Bioactivity and safety confirmed by preclinical research and clinical trials. Some protein kinase inhibitors have been approved by FDA.

• Structurally diverse, medicinally active, and cell permeable.

• Rich documentation with structure, IC₅₀, and customer reviews.

• NMR and HPLC validated to ensure the highest purity.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 2,849 stem cell signaling related compounds supplied as pre-dissolved Solutions or Solid

Solution: 2,750 compounds supplied in 10 mM solution, 92 compounds supplied in 2 mM solution, 7 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice