4′-DTMP
Based on 1 Customer Validation
4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 21253-58-7
- Formula: C13H16N4O3
- Molecular Weight:276.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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eDHFR |
Chemical Information
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CAS No. 21253-58-7
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Appearance Solid
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Molecular Weight 276.30
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Formula C13H16N4O3
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Color Light brown to brown
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SMILES
OC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (180.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.6193 mL | 18.0963 mL | 36.1925 mL | 90.4814 mL |
| 5 mM | 0.7239 mL | 3.6193 mL | 7.2385 mL | 18.0963 mL | |
| 10 mM | 0.3619 mL | 1.8096 mL | 3.6193 mL | 9.0481 mL | |
| 15 mM | 0.2413 mL | 1.2064 mL | 2.4128 mL | 6.0321 mL | |
| 20 mM | 0.1810 mL | 0.9048 mL | 1.8096 mL | 4.5241 mL | |
| 25 mM | 0.1448 mL | 0.7239 mL | 1.4477 mL | 3.6193 mL | |
| 30 mM | 0.1206 mL | 0.6032 mL | 1.2064 mL | 3.0160 mL | |
| 40 mM | 0.0905 mL | 0.4524 mL | 0.9048 mL | 2.2620 mL | |
| 50 mM | 0.0724 mL | 0.3619 mL | 0.7239 mL | 1.8096 mL | |
| 60 mM | 0.0603 mL | 0.3016 mL | 0.6032 mL | 1.5080 mL | |
| 80 mM | 0.0452 mL | 0.2262 mL | 0.4524 mL | 1.1310 mL | |
| 100 mM | 0.0362 mL | 0.1810 mL | 0.3619 mL | 0.9048 mL |
4′-DTMP Related Classifications
HY-W587663 Related Classifications
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