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CM-24

(Synonyms: MK-6018)
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Based on 1 Customer Validation

CM-24 (MK-6018) is a highly selective humanized monoclonal antibody targeting CEACAM1/CD66a. CM-24 binds to the N-terminal domain of CEACAM1, blocks the CEACAM1-CEACAM1 interaction, relieves the co-inhibitory effect on CEACAM1-positive lymphocytes, and enhances the cytotoxic activity of TIL, LAK and NK cells against CEACAM1-positive tumor cells. CM-24 can be used in studies related to tumor immunology, tumor metastasis and thrombosis. For the isotype control of CM-24, refer to Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

  • Purity : 96.02%
  • CAS No.: 1783801-93-3
  • Molecular Weight:144.98 kDa
  • Storage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for CM-24
  • Experimental Validation Results for CM-24
  • CM-24 Chemical Structure
    CM-24 Chemical Structure
CAS No.: 1783801-93-3
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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CM-24 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Immobilized CEACAM1 Protein, Human can bind CM-24. The EC50 for this effect is 3.38 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 HT-29 cells with CM-24 (HY-P990569, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • CM-24 Chemical Structure
    1/16
  • CM-24
  • Immobilized CEACAM1 Protein, Human can bind CM-24. The EC50 for this effect is 3.38 ng/mL.
  • Flow cytometric analysis of 1.5X106 HT-29 cells with CM-24 (HY-P990569, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).