Ir-CA
Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394)-resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9.
For research use only. We do not sell to patients.
- CAS No.: 2870682-93-0
- Formula: C43H35F6IrN5OP
- Molecular Weight:974.95
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Ir-CA shows cytotoxicity against A549, A549R, HLF, BEAS-2B, MCF-7, 4T1 cells with IC50s of 4.4, 4.5, 6.6, 2.3, 2.6, 5.7 μM respectively[1].
Ir-CA is quickly absorbed by the A549R cells (indicated by the red fluorescence after 1 h of incubation)[1].
Ir-CA (10 μM, 2 h) can accumulate in the mitochondria of living A549 and A549R cells (Co-staining experiments of Ir-CA with Mito-Tracker)[1].
Ir-CA (10 μM, 24 h) damages mitochondrial morphology and the mitochondrial function in A549R cells, and induces ROS production[1].
Ir-CA (10 μM, 24 h) induces cell apoptosis in A549R cells via a nonapoptotic/necrotic pathway, and also increases conversion from LC3-I to LC3-II, suggesting the autophagy[1].
Ir-CA (2.5 μM, 24 h) resensitizes the A549R cells to Cisplatin (HY-17394)[1].
Ir-CA (5 μM, 24 h) inhibitS the metastasis of A549R cells via down-regulation of MMPs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ir-CA (5 mg/kg, i.p., once every other day for 14 d) inhibits tumor growth in A549 tumor-bearing Balb/c nude mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2870682-93-0
-
Molecular Weight 974.95
-
Formula C43H35F6IrN5OP
-
SMILES
CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=[N]3C=CC=C6)([C-]7=C(C=CC=C7)C8=[N]4C=CC=C8)[N]9=CC=C(CNC(/C=C/C%10=CC=CC=C%10)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ir-CA Related Classifications
HY-162344 Related Classifications
Powered by Bioz