LDC0496
LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome.
For research use only. We do not sell to patients.
- CAS No.: 2411874-83-2
- Formula: C32H35N5O3
- Molecular Weight:537.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
IC50: 0.152 ± 0.011 μM in Ba/F3 (EGFR-insNPH), 0.162 ± 0.010 μM in Ba/F3 (Her2-insYVMA), 2.660 ± 0.129 in A431[1]
Chemical Information
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CAS No. 2411874-83-2
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Molecular Weight 537.65
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Formula C32H35N5O3
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SMILES
CC(C=CC(C1=C(NC2=NC=C(C=C21)C(OC(C)C)=O)C3=CC=C(C=C3)N4CCN(CC4)C)=C5)=C5NC(C=C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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