A-423579
A-423579 is an orally active non-imidazole histamine H3 receptor antagonist. A-423579 exhibits high affinity and good selectivity for human and rat H3 receptors, and possesses both antagonistic and inverse agonistic activities. A-423579 can effectively reduce body weight in obese rodents, with concomitant decreases in fat content, plasma leptin levels, and triglycerides. A-423579 possesses anti-obesity activity and can be used in the research of obesity and related metabolic disorders.
For research use only. We do not sell to patients.
- CAS No.: 461045-17-0
- Formula: C22H25F2N3O
- Molecular Weight:385.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
More
Biological Activity
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human H3 receptor 8.09 (pkB) |
human H3 receptor 7.71 (pEC50) |
human H3 receptor 8.68 (pKi) |
rat H3 receptor 8.27 (pKi) |
Chemical Information
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CAS No. 461045-17-0
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Molecular Weight 385.45
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Formula C22H25F2N3O
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SMILES
CN([C@@H]1CCN(CCCOC2=C(F)C=C(C3=CC=C(C#N)C=C3)C=C2F)C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hancock AA, et al. Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy. Inflamm Res. 2005 Apr;54 Suppl 1:S27-9. [Content Brief]
[2]. Masaki T, et al. Therapeutic approach of histamine H3 receptors in obesity. Recent Pat CNS Drug Discov. 2007 Nov;2(3):238-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A-423579 Related Classifications
HY-12192 Related Classifications
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