Vopratelimab
Based on 1 Customer Validation
Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 2039148-04-2
- Molecular Weight:145.8 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female A/J, Balb/c and C57BL/6 mice with Sa1/N murine syngeneic tumor model[1]
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Dosage:0.25-0.3 mg/kg
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Administration:Intraperitoneal injection; twice a week, for 2 weeks
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Result:Regressed tumor and protected long-term in the Sa1/N murine syngeneic tumor model.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized ICOS Protein, Human (HEK293, Fc, HY-P72618) can bind Vopratelimab. The EC50 for this effect is 22.71 ng/mL.
Chemical Information
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CAS No. 2039148-04-2
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Appearance Liquid
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Molecular Weight 145.8 kDa
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Color Colorless to light yellow
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SMILES
[Vopratelimab]
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Synonyms
JTX 2011; 37A10
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)