Inositol 4-phosphate
Inositol 4-phosphate (IP1) is an inositol monophosphate isomer derived from the dephosphorylation of I(1,4)P2. Inositol 4-phosphate increases rapidly in GH3 cells after thyrotropin-releasing hormone stimulation. Inositol 4-phosphate can be used in glioma-related research.
For research use only. We do not sell to patients.
- CAS No.: 46495-39-0
- Formula: C6H13O9P
- Molecular Weight:260.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
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- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Inositol 4-phosphate (IP1) accumulates in C6 glioma cells in a time- and concentration-dependent manner upon histamine stimulation (EC50 = 4.1 μM)[1].
Inositol 4-phosphate (I4P) accumulates in GH3 cells following TRH stimulation; its levels rise rapidly within 30 s and continue to increase for up to 30 min; moreover, it is separable from other inositol phosphate isomers using anion-exchange HPLC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 46495-39-0
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Molecular Weight 260.13
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Formula C6H13O9P
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SMILES
O(P(=O)(O)O)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
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Synonyms
IP1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Inositol 4-phosphate Related Classifications
HY-187834 Related Classifications
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