Ioxaglic acid
Ioxaglic acid (P-286) is negatively charged contrast agent, is useful as an inverse indicator for glycosaminoglycan (GAG) used in computed tomography (CT). Ioxaglic acid can be used for imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content.
For research use only. We do not sell to patients.
- CAS No.: 59017-64-0
- Formula: C24H21I6N5O8
- Molecular Weight:1268.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 59017-64-0
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Molecular Weight 1268.88
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Formula C24H21I6N5O8
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SMILES
IC(C(C(NCCO)=O)=C(I)C(C(O)=O)=C1I)=C1NC(CNC(C2=C(C(N(C)C(C)=O)=C(I)C(C(NC)=O)=C2I)I)=O)=O
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Synonyms
P-286
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Carbohydrates and Mucins: Alcian Blue/Alcian Blue-PAS Staining
Alcian Blue (AB) staining is a cationic copper phthalocyanine dye-based histochemical method that binds electrostatically to negatively charged acidic mucopolysaccharides (glycosaminoglycans and sialomucins), enabling visualization of acidic carbohydrate-rich structures such as epithelial mucins, cartilage matrix, and mast cell granules. Periodic Acid-Schiff (PAS) reaction detects neutral mucopolysaccharides and glycoconjugates by oxidizing vicinal diols to aldehydes, which subsequently react with Schiff reagent to produce a magenta signal. The combined Alcian Blue-PAS (AB-PAS) method allows simultaneous differentiation of acidic (blue) and neutral (magenta) mucins in the same tissue section, enabling mucin subtype discrimination in epithelial tissues and pathological lesions.
Purity & Documentation
References
[1]. Gonsette RE, et, al. New contrast media in cerebral angiography: animal experiments and preliminary clinical studies. Invest Radiol. Nov-Dec 1980;15(6 Suppl):S270-4. [Content Brief]
[2]. Baer K, et, al. Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents. APL Bioeng. 2021 Apr 1;5(2):026101. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ioxaglic acid Related Classifications
HY-106586 Related Classifications
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