Isotope-Labeled Vitamins

Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status.

Doxercalciferol-d₃3 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.

(2RS,4R,8R)-δ-Tocopherol-d₄ (Mixture of Diastereomers) is the deuterium labeled (2RS,4R,8R)-δ-Tocopherol (Mixture of Diastereomers).

Pyridoxal phosphate-d₅ is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

Vitamin D3-¹³C₅ is the ¹³C-labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

α-Vitamin E-¹³C₆ is the ¹³C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant.

Isonicotinamide-d₄ is the deuterium labeled Isonicotinamide.

3-epi-25-Hydroxy Vitamin D3-d₆ is the deuterium labeled 3-epi-25-Hydroxy Vitamin D3 (HY-142140). 3-epi-25-Hydroxy Vitamin D3 is the vitamin D metabolite, while vitamin D metabolism highly dependent on macrophage polarization. The C3-epimerase pathway for vitamin D is active in macrophages.

3-Pyridine-2,4,5,6-d₄ -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-carboxylic acid, ethyl ester.

DL-alpha-Tocopherol-d₉ is the deuterium labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB.

Pyridoxine-d₅ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol;Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol;Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

DL-α-Tocopherol acetate-¹³C₄,d₆ is the deuterium and ¹³C labeled DL-α-Tocopherol acetate. DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition.

Niacin-¹⁵N,¹³C₃ is the ¹³C and ¹⁵N labeled Niacin. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases.

Calcitriol-d₃ is the deuterium labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

Folic acid-¹⁵N,¹³C₅ is the ¹³C₅ and ¹⁵N labeled Folic acid (HY-16637).

Ercalcitriol-¹³C,d₃ is the ¹³C- and deuterium labeled Ercalcitriol. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.

l-α-tocopherol acetate-¹³C₄,d₆ is the ¹³C- and deuterium-labeled l-α-tocopherol acetate. l-α-tocopherol acetate is a natural tocopherol and has potent antioxidant activities.

Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

Menaquinone-9-d7 is the deuterated-labeled Menaquinone 9 (HY-131501). Menaquinone 9 is a naphthoquinone-type vitamin K and electron transport component produced by bacteria. Menaquinone 9 is an orally active analog of Vitamin K2 (HY-109569). Menaquinone 9 acts as an ultraviolet-sensitive, photooxidizable substrate that generates more polar photodegradation products under oxygen and ultraviolet irradiation. Menaquinone 9 binds to the αβ dimer of Escherichia coli nitrate reductase, supporting electron transport within the αβ subunit structure of the enzyme. Menaquinone 9 serves as a precursor for bone Menaquinone-4 (HY-B2156). Menaquinone 9 can be used in studies related to metabolic diseases.