Chloroxylenol
Based on 3 publication(s) in Google Scholar
Chloroxylenol is a broad-spectrum antibacterial agent that can be used to control bacteria, algae, fungi and viruses.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 88-04-0
- Formula: C8H9ClO
- Molecular Weight:156.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chloroxylenol
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Biological Activity
Chloroxylenol (0-250 μM, 24 or 48 h) inhibits the viability, proliferation, migration and invasion, and sphere formation, and induces apoptosis in HCT116 and SW480 cells by inhibiting Wnt/β-catenin signaling pathway[3].
Chloroxylenol (0-250 μM, 24 h) inhibits nuclear translocation of β-catenin in HCT116 and SW480 cells[3].
Chloroxylenol (0-250 μM, 7 days) inhibits the growth of CRC organoids[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 and SW480 CRC cells
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Concentration:62.5-250 μM
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Incubation Time:24 h
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Result:Decreased mRNA level Axin2, Survivin and LGR5, which indicates the antagonistic effect of Chloroxylenol on the Wnt/β-catenin signaling.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MC38 cell xenograft model[3]
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Dosage:5 mg/kg
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Administration:i.p., on days 0, 2, 4, 6, 8 and 10
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Result:Reduced umor volume and weight.
Reduced tumor cell density (H&E).
Inhibited the expression of cancer stemness marker LGR5 in the tumor tissue, as well as the expression levels of LGR5 and SOX2.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 88-04-0
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Appearance Solid
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Molecular Weight 156.61
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Formula C8H9ClO
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Color White to off-white
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SMILES
OC1=CC(C)=C(Cl)C(C)=C1
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Synonyms
p-Chloro-m-xylenol; PCMX
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Aquat Toxicol
Chloroxylenol disrupts Rana chensinensis tadpoles metabolic homeostasis via gut microbiota-dysregulated: A multi-omics perspective. [Abstract]2025 Sep 13:289:107576. PMID: 40961862 -
Aquat Toxicol
Chronic toxic effects of chloroxylenol exposure on Rana chensinensis: Insights from endochondral ossfication. [Abstract]2024 Oct 30:277:107140. PMID: 39489103
Solvent & Solubility
DMSO : ≥ 100 mg/mL (638.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
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- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Holt GS, et al. Shigatoxin encoding Bacteriophage ϕ24B modulates bacterial metabolism to raise antimicrobial tolerance. Sci Rep. 2017 Jan 20;7:40424. [Content Brief]
[2]. Wood A, et al. The action of three antiseptics/disinfectants against enveloped and non-enveloped viruses. J Hosp Infect. 1998 Apr;38(4):283-95. [Content Brief]
[3]. Sun Q, et al. Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer. Int J Oncol. 2023 Nov;63(5):121. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 6.3853 mL | 31.9264 mL | 63.8529 mL | 159.6322 mL |
| 5 mM | 1.2771 mL | 6.3853 mL | 12.7706 mL | 31.9264 mL | |
| 10 mM | 0.6385 mL | 3.1926 mL | 6.3853 mL | 15.9632 mL | |
| 15 mM | 0.4257 mL | 2.1284 mL | 4.2569 mL | 10.6421 mL | |
| 20 mM | 0.3193 mL | 1.5963 mL | 3.1926 mL | 7.9816 mL | |
| 25 mM | 0.2554 mL | 1.2771 mL | 2.5541 mL | 6.3853 mL | |
| 30 mM | 0.2128 mL | 1.0642 mL | 2.1284 mL | 5.3211 mL | |
| 40 mM | 0.1596 mL | 0.7982 mL | 1.5963 mL | 3.9908 mL | |
| 50 mM | 0.1277 mL | 0.6385 mL | 1.2771 mL | 3.1926 mL | |
| 60 mM | 0.1064 mL | 0.5321 mL | 1.0642 mL | 2.6605 mL | |
| 80 mM | 0.0798 mL | 0.3991 mL | 0.7982 mL | 1.9954 mL | |
| 100 mM | 0.0639 mL | 0.3193 mL | 0.6385 mL | 1.5963 mL |
Chloroxylenol Related Classifications
HY-B1414 Related Classifications
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