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EIF3H - eukaryotic translation initiation factor 3 subunit H Gene

Also Known as EIF3S3; eIF3-p40; eIF3-gamma

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8667

About EIF3H

Cytogenetic location: 8q23.3-q24.11 Genomic coordinates (GRCh38): 8:116,642,130-116,766,374 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues.

Summary

Enables Deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate Cancer. [provided by Alliance of Genome Resources, Apr 2022]

EIF3H Products (1)

mRNA	Protein	Name
NM_003756.3	NP_003747.1	eukaryotic translation initiation factor 3 subunit H

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables metal-dependent deubiquitinase activity	IDA IDA: Inferred from direct assay	32269044	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12812986	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	32269044	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3H Protein Structure

JAB

0
100
200
300
352 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 3 subunit H	eIF-3-gamma

EIF3H Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF3H	O15372	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	EIF3H	O15372	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	EIF3H	O15372	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	EIF3H	O15372	SORBS2	Homo sapiens	O94875-10	Validated Y2H	32296183
Intra	EIF3H	O15372	DISC1	Homo sapiens	Q9NRI5-1	Y2H	17043677
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	18599441
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	33961781
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	28514442
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	SLCA	18599441
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	19615732
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Pull Down	23623729
Intra	EIF3H	O15372	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	19615732
Intra	EIF3H	O15372	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Intra	EIF3H	O15372	DISC1	Homo sapiens	Q9NRI5	Y2H	12812986
Intra	EIF3H	O15372	EIF3F	Homo sapiens	O00303	Anti Tag CoIP	18599441
Intra	EIF3H	O15372	EIF3F	Homo sapiens	O00303	Pull Down	23623729
Intra	EIF3H	O15372	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
Intra	EIF3H	O15372	NCK2	Homo sapiens	O43639	Validated Y2H	32296183
Intra	EIF3H	O15372	NCK2	Homo sapiens	O43639	Y2H Array	32296183
Intra	EIF3H	O15372	SORBS3	Homo sapiens	O60504	Validated Y2H	32296183
Intra	EIF3H	O15372	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	EIF3H	O15372	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	EIF3H	O15372	ABI3	Homo sapiens	Q9P2A4	Y2H Pooling	16189514
Intra	EIF3H	O15372	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	EIF3H	O15372	EIF3CL	Homo sapiens	B5ME19	Anti Tag CoIP	33961781
Intra	EIF3H	O15372	EIF3CL	Homo sapiens	B5ME19	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF3H Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86859	EIF3H Antibody (YA6552)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Trichorhinophalangeal Syndrome, Type Ii	Langer-Giedion Syndrome Lgs Trichorhinophalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome Type 2 TRPS2 Monosomy 8q24.1 Chromosome 8q24.1 Deletion Syndrome Deletion 8q24.1 Giedion-Langer Syndrome Trichorhinophalangeal Dysplasia Type Ii Langer Giedion Syndrome Trps 2 Tricho-Rhino-Phalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome With Exostosis Trps Ii Tricho-Rhino-Phalangeal Syndrome 2 8q24.1 Microdeletion Syndrome 8q24.1 Deletion Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04264	EIF3H Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22481	Eif3h Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF3H	RGD	RGD:735178
Felis catus	EIF3H	VGNC	VGNC:81651
Mus musculus	EIF3H	MGD	MGI:1915385
Macaca mulatta	EIF3H	VGNC	VGNC:72189
Bos taurus	EIF3H	VGNC	VGNC:28398
Canis familiaris	EIF3H	VGNC	VGNC:40274
Others	EIF3H	NCBI