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Cat. No.: HY-185287

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TUG-1609

TUG-1609 is a fluorescent tracer targeting free fatty acid receptor 2 (FFA2/GPR43) with a K_d value of 65.1 nM.

For research use only. We do not sell to patients.

CAS No.: 2101952-37-6
Formula: C₃₆H₃₆F₃N₇O₆S
Molecular Weight:751.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TUG-1609 Chemical Structure

CAS No.: 2101952-37-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

TUG-1609 is a fluorescent tracer targeting free fatty acid receptor 2 (FFA2/GPR43) with a K_d value of 65.1 nM^[1].

All Free Fatty Acid Receptor Isoforms :

In Vitro

TUG-1609 acts as an antagonist of human FFA2 in Flp-In™ T-REx™ 293 cells expressing hFFA2-eYFP, inhibiting propionate-mediated IP1 accumulation with a pIC₅₀ of 6.57^[1].
TUG-1609 (2 h) binds to human FFA2 in membrane preparations from Flp-In™ T-REx™ 293 cells expressing hFFA2-eYFP, displacing [³H]-1 with a pK_i of 7.31^[1].
TUG-1609 (0-500 nM; 2 h) binds to NLuc-tagged human FFA2 in membrane preparations from Flp-In™ T-REx™ 293 cells with a K_d of 65.1 nM, a koff of 0.0249 min^-1, and a kon of 368,000 M^-1min^-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2101952-37-6
Molecular Weight 751.77
Formula C₃₆H₃₆F₃N₇O₆S
SMILES

O=C(CCCN(CC1=CC=C(C(F)(F)F)C=C1)C(C2(C)N(CC2)C(CC3=CSC4=C3C=CC=C4)=O)=O)NCCCNC5=CC=C([N+]([O-])=O)C6=NON=C65
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hansen AH, et al. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43). J Med Chem. 2017;60(13):5638-5645. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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TUG-1609

All Free Fatty Acid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TUG-1609 Related Classifications

HY-185287 Related Classifications