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Cat. No.: HY-187355

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VU6077564

VU6077564 is a reversible competitive antagonist of M1 mAChR, with an IC₅₀ of 31 nM in human (CHO cells) and 39.5 nM in rats. VU6077564 promotes axon growth of sensory neurons from adult rat dorsal root ganglia cultured in vitro. VU6077564 can be used for the research of peripheral neuropathy.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₇FN₆O₃S
Molecular Weight:522.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VU6077564 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

mAChR1

All mAChR Isoforms :

In Vitro

VU6077564 potently and selectively inhibits the human M₁ muscarinic acetylcholine receptor in hM₁-CHO cells, with an hM₁ IC₅₀ of 31 nM^[1].
VU6077564 (10-point serial dilution curves) potently inhibits rat M₁ muscarinic acetylcholine receptors, with an rM₁ IC₅₀ of 39.5 nM and an rM₁ K_B of 12 nM^[1].
VU6077564 (0-1000 nM; 42 h) promotes axonal growth in cultured adult rat DRG sensory neurons, with an ED₅₀ of 55 nM. It achieves a maximum 2-fold induction effect at 1000 nM without reducing neuronal viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL_plasma	V_ss	T_1/2 (Elimination)
Rat^[1]	0.2 mg/kg	i.v.	71.7 mL/min/kg	27.6 L/kg	35.2 h

Chemical Information

Molecular Weight 522.59
Formula C₂₆H₂₇FN₆O₃S
SMILES

O=S(C1=C2C=CC=NC2=C(F)C=C1)(N[C@H]3C[C@@H](C(N4[C@@H](C)CN(C5=NC(C)=C(C#N)C=C5)CC4)=O)C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Berida TI, et al. Discovery of VU6077564: A Selective M Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons. ACS chemical neuroscience. 2026 Jul 15;17(14):2739-2751. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VU6077564

All mAChR Isoforms