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Etentamig

(Synonyms: ABBV-383; TNB 383B)
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Based on 1 Customer Validation

Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases.

For research use only. We do not sell to patients.

  • Purity: 99%
  • CAS No.: 2490552-52-6
  • Molecular Weight:123.8 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Etentamig
  • Experimental Validation Results for Etentamig
  • Experimental Validation Results for Etentamig
  • Experimental Validation Results for Etentamig
  • Etentamig Chemical Structure
    Etentamig Chemical Structure
CAS No.: 2490552-52-6
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Etentamig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    G4_L-kappa_VH-VH-h-CH2-CH3

  • 1/16

    Loaded ABBV-383 on AHC2 biosensor, can bind BCMA/TNFRSF17 Protein, Human (HEK293, His, HY-P72847) with an affinity constant of 1.731E-11 M as determined in BLI assay.

  • 1/16

    Loaded ABBV-383 on AHC2 biosensor, can bind CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His, HY-P70434) with an affinity constant of 3.674E-07 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 Juakat cells with Etentamig (HY-P990785, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Etentamig Chemical Structure
    1/16
  • Etentamig
  • Loaded ABBV-383 on AHC2 biosensor, can bind BCMA/TNFRSF17 Protein, Human (HEK293, His, HY-P72847) with an affinity constant of 1.731E-11 M as determined in BLI assay.
  • Loaded ABBV-383 on AHC2 biosensor, can bind CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His, HY-P70434) with an affinity constant of 3.674E-07 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 Juakat cells with Etentamig (HY-P990785, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • G4_L-kappa_VH-VH-h-CH2-CH3