AD 01
Based on 2 publication(s) in Google Scholar
AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 959961-23-0
- Formula: C115H187N33O42
- Molecular Weight:2703.94
-
Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AD 01
More
Biological Activity
AD-01 (1-100 nM; 24 h) up-regulates the expression of CD44[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 and HMEC-1 cells
-
Concentration:1 nM, 100 nM
-
Incubation Time:24 h
-
Result:Up-regulated CD44 expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Balb-c severe compromised immuno-deficient (SCID) mice[1].
-
Dosage:0.3 mg/kg/day.
-
Administration:I,P., for 14 days.
-
Result:Significantly lowered the tumor size.
Chemical Information
-
CAS No. 959961-23-0
-
Appearance Solid
-
Molecular Weight 2703.94
-
Formula C115H187N33O42
-
Color White to off-white
-
Sequence
Gln-Ile-Arg-Gln-Gln-Pro-Arg-Asp-Pro-Pro-Thr-Glu-Thr-Leu-Glu-Leu-Glu-Val-Ser-Pro-Asp-Pro-Ala-Ser
-
Sequence Shortening
QIRQQPRDPPTETLELEVSPDPAS
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Chem Biol Interact
Targeting trophoblast cell mitochondrial dysfunction in preeclampsia via drug repurposing. [Abstract]2026 Jan 25:424:111883. PMID: 41407245 -
Solvent & Solubility
H2O : ≥ 100 mg/mL (36.98 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (279 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Andrea Valentine, et al. FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin Cancer Res. 2011 Mar 1;17(5):1044-56. [Content Brief]
[2]. Anita Yakkundi, et al. The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS One. 2013;8(2):e55075. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3698 mL | 1.8492 mL | 3.6983 mL | 9.2458 mL |
| 5 mM | 0.0740 mL | 0.3698 mL | 0.7397 mL | 1.8492 mL | |
| 10 mM | 0.0370 mL | 0.1849 mL | 0.3698 mL | 0.9246 mL | |
| 15 mM | 0.0247 mL | 0.1233 mL | 0.2466 mL | 0.6164 mL | |
| 20 mM | 0.0185 mL | 0.0925 mL | 0.1849 mL | 0.4623 mL | |
| 25 mM | 0.0148 mL | 0.0740 mL | 0.1479 mL | 0.3698 mL | |
| 30 mM | 0.0123 mL | 0.0616 mL | 0.1233 mL | 0.3082 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AD 01 Related Classifications
HY-P2284 Related Classifications
Powered by Bioz