Cat. No.: HY-152852A

Mefatinib

(Synonyms: Mifanertinib dimaleate)

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Based on 1 Customer Validation

Mefatinib (Mifanertinib dimaleate) is an orally active EGFR and HER2 kinase inhibitor with IC₅₀ values of 0.4 nM and 11.7 nM, respectively. Mefatinib inhibits tumor growth in mouse models of lung cancer xenografts that overexpress EGFR/HER2, carry EGFR mutations, or carry Erlotinib (HY-50896)-resistant EGFR double mutations. Mefatinib can be used for the research of advanced EGFR-mutant non-small cell lung cancer.

For research use only. We do not sell to patients.

Purity: 98.90%
CAS No.: 1989592-50-8
Formula: C₂₉H₂₇ClF₃N₅O₁₀
Molecular Weight:698.00

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Mefatinib Chemical Structure

CAS No.: 1989592-50-8

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Quantity

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* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

EGFR

0.4 nM (IC₅₀)

HER2

11.7 nM (IC₅₀)

All EGFR Isoforms :

In Vivo

Mefatinib exhibits potent anti-tumor activity in a nude mouse xenograft model of erlotinib (HY-50896)-resistant EGFR^L858R/T790M-mutant non-small cell lung cancer^[1].
Mefatinib (0.2 mg/kg) achieves 99.6% tumor growth inhibition in a nude mouse xenograft model of human lung adenocarcinoma HCC827^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1989592-50-8
Appearance Solid
Molecular Weight 698.00
Formula C₂₉H₂₇ClF₃N₅O₁₀
Color Off-white to light yellow
SMILES

OC(/C=C\C(O)=O)=O.O=C(NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1OC(F)F)/C=C/CN(C)C.OC(/C=C\C(O)=O)=O
Synonyms

Mifanertinib dimaleate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (143.27 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4327 mL

7.1633 mL

14.3266 mL

5 mM

0.2865 mL

1.4327 mL

2.8653 mL

10 mM

0.1433 mL

0.7163 mL

1.4327 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang P, et al. Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study. Signal transduction and targeted therapy. 2021 Nov 01;6(1):374. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.4327 mL	7.1633 mL	14.3266 mL	35.8166 mL
	5 mM	0.2865 mL	1.4327 mL	2.8653 mL	7.1633 mL
	10 mM	0.1433 mL	0.7163 mL	1.4327 mL	3.5817 mL
	15 mM	0.0955 mL	0.4776 mL	0.9551 mL	2.3878 mL
	20 mM	0.0716 mL	0.3582 mL	0.7163 mL	1.7908 mL
	25 mM	0.0573 mL	0.2865 mL	0.5731 mL	1.4327 mL
	30 mM	0.0478 mL	0.2388 mL	0.4776 mL	1.1939 mL
	40 mM	0.0358 mL	0.1791 mL	0.3582 mL	0.8954 mL
	50 mM	0.0287 mL	0.1433 mL	0.2865 mL	0.7163 mL
	60 mM	0.0239 mL	0.1194 mL	0.2388 mL	0.5969 mL
	80 mM	0.0179 mL	0.0895 mL	0.1791 mL	0.4477 mL
	100 mM	0.0143 mL	0.0716 mL	0.1433 mL	0.3582 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

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Mefatinib

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Differentiation Inducing Compound Library

Orally Active Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cytokine Inhibitors Library

Anti-Drug-Resistant Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

All EGFR Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Mefatinib Related Classifications

HY-152852A Related Classifications