SEW84
Based on 1 Customer Validation
SEW84 is an inhibitor of Aha1-stimulated Hsp90 (ASH) ATPase activity. SEW84 inhibits Aha1-stimulated Hsp90 (ASH) activity with an IC50 value of 0.3 μM. SEW84 can be used in the study of protein deposition diseases.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 259089-67-3
- Formula: C19H14F4N4OS
- Molecular Weight:422.40
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.3 μM (ASH); 1.3 μM (GR-dependent luciferase expression); 0.7 μM (AR-dependent luciferase expression)[1]
SEW84 (5 μM) shows complete inhibition of ASH activity with an IC50 value of 0.3 μM[1].
SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 values of 1.3 and 0.7 μM, respectively[1].
SEW84 (0-20 μM) inhibits the Hsp90-Dependent folding of firefly luciferase[1].
SEW84 (0, 3, 10, 30 μM; 24 h) specifically clears phosphorylated tau[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:tau-0N4R-HeLa cells
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Concentration:0, 3, 10, 30 μM
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Incubation Time:24 h
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Result:Reduced the expression of phospho-Tau.
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Cell Line:RFP-tau-0N4R HEK cells
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Concentration:1, 10 μM
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Incubation Time:24 h
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Result:Completely abrogated the aggregation of tau.
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Cell Line:LNCaP and 22Rv1 cells
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Observed a synergistic decrease in LNcaP cell proliferation when combined 1 μM GA with 10 μM SEw84.
Chemical Information
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CAS No. 259089-67-3
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Appearance Solid
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Molecular Weight 422.40
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Formula C19H14F4N4OS
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Color White to off-white
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SMILES
O=C(C1=CC=CN1C2=CC=C(C=C2)F)NNC(NC3=CC=CC(C(F)(F)F)=C3)=S
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Synonyms
SEW04784
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (295.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3674 mL | 11.8371 mL | 23.6742 mL | 59.1856 mL |
| 5 mM | 0.4735 mL | 2.3674 mL | 4.7348 mL | 11.8371 mL | |
| 10 mM | 0.2367 mL | 1.1837 mL | 2.3674 mL | 5.9186 mL | |
| 15 mM | 0.1578 mL | 0.7891 mL | 1.5783 mL | 3.9457 mL | |
| 20 mM | 0.1184 mL | 0.5919 mL | 1.1837 mL | 2.9593 mL | |
| 25 mM | 0.0947 mL | 0.4735 mL | 0.9470 mL | 2.3674 mL | |
| 30 mM | 0.0789 mL | 0.3946 mL | 0.7891 mL | 1.9729 mL | |
| 40 mM | 0.0592 mL | 0.2959 mL | 0.5919 mL | 1.4796 mL | |
| 50 mM | 0.0473 mL | 0.2367 mL | 0.4735 mL | 1.1837 mL | |
| 60 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9864 mL | |
| 80 mM | 0.0296 mL | 0.1480 mL | 0.2959 mL | 0.7398 mL | |
| 100 mM | 0.0237 mL | 0.1184 mL | 0.2367 mL | 0.5919 mL |
SEW84 Related Classifications
HY-152184 Related Classifications
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