1'-Hydroxy bufuralol
Based on 1 Customer Validation
1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.62%
- CAS 番号: 57704-16-2
- 分子式: C16H23NO3
- 分子量:277.36
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CYP2 |
Bufuralol is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 57704-16-2
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性状 <41°C Solid,>49°C Liquid
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分子量 277.36
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分子式 C16H23NO3
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Color Off-white to light yellow
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SMILES
CC(C1=C2OC(C(CNC(C)(C)C)O)=CC2=CC=C1)O
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別名
Ro 03-7410
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82(4):668-78. [Content Brief]
[2]. H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46(3):568-77. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
1'-Hydroxy bufuralol 関連分類
HY-122277 関連分類
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