3-MPPI
3-MPPI is a GPCR ligand with high selectivity for α1-adrenergic receptor, with a Ki value of 0.21 nM for α1-adrenergic receptor and 50 nM for 5-HT1A receptor. 3-MPPI modulates the α1-adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 133399-65-2
- 分子式: C23H25N5O3
- 分子量:419.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adrenergic Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | Inhibition |
9.14 %
Compound: 3-MPPI
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
10.21203/rs.3.rs-23951/v1 |
3-MPPI (compound RN5) derivatives exhibit exceptional α1-adrenoceptor (α1-AR) affinity (Ki = 2.71 nM) and selectivity over 5-HT1A receptors (5-HT1A/α1 ratio > 3500)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 133399-65-2
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分子量 419.49
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分子式 C23H25N5O3
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SMILES
O=C1NC=2C=3C=CC=CC3NC2C(=O)N1CCN4CCN(C=5C=CC=CC5OC)CC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
3-MPPI 関連分類
HY-101008 関連分類
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- 3-MPPI
- 133399-65-2
- Adrenergic Receptor
- G protein-coupled Bile Acid Receptor 1
- benign prostatic hyperplasia
- stress-induced anxiety-like behavioral responses
- l-dopa-induced dyskinesia
- GPCR ligand
- α1-adrenoceptor
- lower urinary tract symptoms
- hypertension
- myocardial hypertrophy
- 5-HT1A receptor
- human α1?-AR
- Inhibitor
- inhibitor
- inhibit