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製品番号: HY-101008

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3-MPPI

3-MPPI is a GPCR ligand with high selectivity for α₁-adrenergic receptor, with a K_i value of 0.21 nM for α₁-adrenergic receptor and 50 nM for 5-HT₁A receptor. 3-MPPI modulates the α₁-adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 133399-65-2
分子式: C₂₃H₂₅N₅O₃
分子量:419.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-MPPI 構造式

CAS 番号: 133399-65-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Adrenergic Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	Inhibition	9.14 % Compound: 3-MPPI	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

体外実験

3-MPPI (compound RN5) derivatives exhibit exceptional α₁-adrenoceptor (α₁-AR) affinity (K_i = 2.71 nM) and selectivity over 5-HT₁A receptors (5-HT₁A/α₁ ratio > 3500)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 133399-65-2
分子量 419.49
分子式 C₂₃H₂₅N₅O₃
SMILES

O=C1NC=2C=3C=CC=CC3NC2C(=O)N1CCN4CCN(C=5C=CC=CC5OC)CC4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pittalà V, et al. Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors. Bioorg Med Chem. 2011 Sep 1;19(17):5260-76. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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