710674-S

710674-S exhibits moderate in vitro antibacterial activity against a variety of anaerobic bacteria in the anaerobic agar plate dilution assay (MICs 12.5-50 μg/mL)^[1].
710674-S exhibits moderate in vitro antibacterial activity against Gram-positive aerobic bacteria (MICs 6.25-100 μg/mL) and no activity against Gram-negative aerobic bacteria in agar plate dilution assays^[1].

710674-S (1.25-80 μg/mL (C. albicans), 0.16-20 μg/mL (T. rubrum); 2, 5, 10 days (C. albicans), 7, 14, 21 days (T. rubrum)) exhibits antifungal activity against Candida albicans IFO 1060, and this activity is significantly enhanced in alkaline medium (with an MIC of 1.25 μg/mL at pH 10); in liquid broth assays, its activity against Trichophyton rubrum IFO 5808 remains consistently strong over the pH range of 6-10^[1].
710674-S exhibits antifungal activity against Candida species and dermatophytes, but the addition of horse blood components to agar medium reduces this activity, with red blood cells exerting a stronger inhibitory effect on the activity than plasma^[1].
710674-S exhibits broad-spectrum in vitro antifungal activity; in agar plate dilution assays, it shows particularly potent activity against dermatophytes (MICs 0.16-1.25 μg/mL), moderate activity against dimorphic/filamentous fungi (MICs 0.31-5 μg/mL), and also moderate activity against most yeasts (MICs 10-40 μg/mL)^[1].