7ACC1
Based on 10 publication(s) in Google Scholar
7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 50995-74-9
- 分子式: C14H15NO4
- 分子量:261.27
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Anti-Cancer Metabolism Compound Library
HY-L083
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Targeted Diversity Library
HY-L099
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Lactic Acid Metabolic Compound Library
HY-L204
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High-Throughput Bioactive Compound Library
HY-L205
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Anti-Cancer Compound Library
HY-L025
MedChemExpress（MCE）の使用を引用している文献 7ACC1
More- Cell Metab. 2021 Oct 5;33(10):2021-2039.e8. [Abstract]
- Microbiome. 2022 Dec 15;10(1):226. [Abstract]
- Cancer Cell Int. 2019 Jun 28:19:170. [Abstract]
- J Biol Chem. 2022 Feb;298(2):101554. [Abstract]
- Exp Cell Res. 2022 Mar 15;412(2):113044. [Abstract]
- Cancer Med. 2018 Sep;7(9):4690-4700. [Abstract]
- Aesthetic Plast Surg. 2024 Dec;48(23):5136-5146. [Abstract]
- bioRxiv. 2026 Mar 10.
- J Oncol. 2022 Sep 26;2022:3659714. [Abstract]
- Research Square Preprint. 2021 Aug.
Customer Validation & Images
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WB
生物活性
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MCT1 |
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Cell Line
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Type | Value | Description | References |
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| 4T1 | IC50 |
>100 μM
Compound: 7
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Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell proliferation by MTT assay
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[PMID: 34626786] |
| HepG2 | IC50 |
>100 μM
Compound: 10
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
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[PMID: 28666736] |
| MCF-10A | IC50 |
>100 μM
Compound: 7
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation by MTT assay
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[PMID: 34626786] |
| MCF7 | IC50 |
>100 μM
Compound: 10
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Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
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[PMID: 28666736] |
| MDA-MB-231 | IC50 |
>100 μM
Compound: 10
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
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[PMID: 28666736] |
| MDA-MB-231 | IC50 |
>100 μM
Compound: 7
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by MTT assay
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[PMID: 34626786] |
| MDA-MB-231 | IC50 |
>50 μM
Compound: 11
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 37602711] |
| SiHa | EC50 |
1.8 μM
Compound: 17
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Cytotoxicity against human SiHa cells in lactate-containing medium after 72 hrs by MTT assay
Cytotoxicity against human SiHa cells in lactate-containing medium after 72 hrs by MTT assay
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[PMID: 24095010] |
| SiHa | IC50 |
0.86 μM
Compound: 17
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Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting
Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting
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[PMID: 24095010] |
| SiHa | IC50 |
250 nM
Compound: 17
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Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting
Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting
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[PMID: 24095010] |
| SK-HEP1 | IC50 |
>100 μM
Compound: 10
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Antiproliferative activity against human SKHEP1 cells after 48 hrs by MTT assay
Antiproliferative activity against human SKHEP1 cells after 48 hrs by MTT assay
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[PMID: 28666736] |
| WiDr | IC50 |
>100 μM
Compound: 7
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Antiproliferative activity against human WiDr cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human WiDr cells assessed as inhibition of cell proliferation by MTT assay
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[PMID: 34626786] |
7ACC1 (10 μM, 0-96 h) attenuates the viability, decreases cell migration and invasion in co-culturing conditions of 786-O cells and HUVECs[1].
7ACC1 (10 μM, 24 h) inhibits the protein expressions of MCT1 and MCT4, down-regulates the extracellular lactate levels in co-culturing conditions of 786-O cells and HUVECs[1].
7ACC1 (0-1 μM, 24 h) inhibit the influx but not the efflux of lactate in cancer cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:786-O cells and HUVECs
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Concentration:10 µM
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Incubation Time:24 h
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Result:Attenuated the protein expressions of MCT1 and MCT4 in co-culturing of 786-O cells and HUVECs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:mice bearing tumors, including cervix cancer SiHa xenografts but also tumors derived from human colon cancer cells HCT116 and bladder cancer cells UM-UC3[2]
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Dosage:3 mg/kg
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Administration:i.p., daily for 12 days
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Result:Led to significant SiHa and HCT116 tumor growth delays in mice bearing tumors.
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化学情報
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CAS 番号 50995-74-9
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性状 Solid
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分子量 261.27
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分子式 C14H15NO4
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Color Orange to red
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SMILES
O=C(C1=CC2=CC=C(N(CC)CC)C=C2OC1=O)O
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別名
DEAC; Coumarin D 1421; D 1421
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (10)
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Journal Impact Factor
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Most Recent
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Cell Metab
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy. [Abstract]2021 Oct 5;33(10):2021-2039.e8. PMID: 34508696 -
Microbiome
Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders. [Abstract]2022 Dec 15;10(1):226. PMID: 36517893 -
Cancer Cell Int
Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. [Abstract]2019 Jun 28:19:170. PMID: 31297034 -
J Biol Chem
Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. [Abstract]2022 Feb;298(2):101554. PMID: 34973337 -
Exp Cell Res
ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer. [Abstract]2022 Mar 15;412(2):113044. PMID: 35093305 -
Cancer Med
Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma. [Abstract]2018 Sep;7(9):4690-4700. PMID: 30051648
7ACC1 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2018 Sep;7(9):4690-4700. [Abstract]
The protein expression of MCT4 in the murine breast cancer cell line 4T1 treated with 7ACC1 (0.1 mM) or transfected with different ShMCT4 vectors.
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Aesthetic Plast Surg
Poly-L-Lactic Acid Reduces the Volume of Dermal Adipose Tissue Through its Metabolite Lactate. [Abstract]2024 Dec;48(23):5136-5146. PMID: 39060798 -
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J Oncol
2022 Sep 26;2022:3659714. PMID: 36199799 -
溶剤 & 溶解度
DMSO : 33.33 mg/mL (127.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Guo C, et al. Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. Cancer Cell Int. 2019 Jun 28;19:170. [Content Brief]
[2]. Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8275 mL | 19.1373 mL | 38.2746 mL | 95.6865 mL |
| 5 mM | 0.7655 mL | 3.8275 mL | 7.6549 mL | 19.1373 mL | |
| 10 mM | 0.3827 mL | 1.9137 mL | 3.8275 mL | 9.5686 mL | |
| 15 mM | 0.2552 mL | 1.2758 mL | 2.5516 mL | 6.3791 mL | |
| 20 mM | 0.1914 mL | 0.9569 mL | 1.9137 mL | 4.7843 mL | |
| 25 mM | 0.1531 mL | 0.7655 mL | 1.5310 mL | 3.8275 mL | |
| 30 mM | 0.1276 mL | 0.6379 mL | 1.2758 mL | 3.1895 mL | |
| 40 mM | 0.0957 mL | 0.4784 mL | 0.9569 mL | 2.3922 mL | |
| 50 mM | 0.0765 mL | 0.3827 mL | 0.7655 mL | 1.9137 mL | |
| 60 mM | 0.0638 mL | 0.3190 mL | 0.6379 mL | 1.5948 mL | |
| 80 mM | 0.0478 mL | 0.2392 mL | 0.4784 mL | 1.1961 mL | |
| 100 mM | 0.0383 mL | 0.1914 mL | 0.3827 mL | 0.9569 mL |
7ACC1 関連分類
HY-D0067 関連分類
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