アフロクアロン
Based on 1 Customer Validation
Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 56287-74-2
- 分子式: C16H14FN3O
- 分子量:283.30
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Afloqualone (oral administration; 10-35 mg/kg; single dose) can relax γ-rigidity and α-rigidity in rats in a dose-dependent manner[1].
Afloqualone (oral administration; 5-10 mg/kg; single dose) inhibits vestibular nystagmus in a dose-dependent manner in spinalized cats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 56287-74-2
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性状 Solid
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分子量 283.30
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分子式 C16H14FN3O
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Color White to off-white
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SMILES
O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3
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別名
Afloqualone; HQ-495
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : 116.67 mg/mL (411.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32(3):427-38. [Content Brief]
[2]. Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50(4):515-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5298 mL | 17.6491 mL | 35.2983 mL | 88.2457 mL |
| 5 mM | 0.7060 mL | 3.5298 mL | 7.0597 mL | 17.6491 mL | |
| 10 mM | 0.3530 mL | 1.7649 mL | 3.5298 mL | 8.8246 mL | |
| 15 mM | 0.2353 mL | 1.1766 mL | 2.3532 mL | 5.8830 mL | |
| 20 mM | 0.1765 mL | 0.8825 mL | 1.7649 mL | 4.4123 mL | |
| 25 mM | 0.1412 mL | 0.7060 mL | 1.4119 mL | 3.5298 mL | |
| 30 mM | 0.1177 mL | 0.5883 mL | 1.1766 mL | 2.9415 mL | |
| 40 mM | 0.0882 mL | 0.4412 mL | 0.8825 mL | 2.2061 mL | |
| 50 mM | 0.0706 mL | 0.3530 mL | 0.7060 mL | 1.7649 mL | |
| 60 mM | 0.0588 mL | 0.2942 mL | 0.5883 mL | 1.4708 mL | |
| 80 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1031 mL | |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3530 mL | 0.8825 mL |
Afloqualone 関連分類
HY-B1833 関連分類
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