CGP 25454A
Based on 1 Customer Validation
CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.65%
- CAS 番号: 104391-26-6
- 分子式: C15H21Cl2N3O2
- 分子量:346.25
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Dopamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
CGP 25454A (0.5-10 μM, 15 min) elicits a reproducible and concentration-dependent increase of the release of both DA and ACh in rat striatal slices with an increase by 62±3% and 100±7% at 10 μM. CGP 25454A is 12.9 fold more potent at pre- than post-synaptic DA receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CGP 25454A (0.5-100 mg/kg, i.p., 10-60 min) exerts opposite effects with a slight behavioral stimulation at low doses and a clear-cut central depressant action in the higher dose range[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Tif rats with Amphetamine-induced hyperactivity[1]
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Dosage:0.5-100 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Did not modify ambulation but increased rearing at 2.5 and 10mg/kg, started to produce sedation at 30 mg/kg and sedation became strong at 100 mg/kg as rats were almost motionless and none of them were cataleptic.
化学情報
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CAS 番号 104391-26-6
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性状 Solid
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分子量 346.25
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分子式 C15H21Cl2N3O2
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Color White to off-white
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SMILES
O=C(NCCN(CC)CC)C1=CC(C#N)=C(Cl)C=C1OC.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : ≥ 3.5 mg/mL (10.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8881 mL | 14.4404 mL | 28.8809 mL | 72.2022 mL |
| 5 mM | 0.5776 mL | 2.8881 mL | 5.7762 mL | 14.4404 mL | |
| 10 mM | 0.2888 mL | 1.4440 mL | 2.8881 mL | 7.2202 mL |
CGP 25454A 関連分類
HY-100454 関連分類
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