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DMH-1

15 Cited Publications
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Based on 15 publication(s) in Google Scholar

DMH-1 is a selective BMP inhibitor. DMH-1 upregulates the expression of SOX1. DMH-1 increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons.

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  • 純度: 99.93%
  • CAS 番号: 1206711-16-1
  • 分子式: C24H20N4O
  • 分子量:380.44
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • DMH-1 Chemical Structure
    DMH-1 構造式
  • Experimental Validation Results for DMH-1
  • Experimental Validation Results for DMH-1
  • Experimental Validation Results for DMH-1
CAS 番号: 1206711-16-1
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  • DMH-1 Chemical Structure
    DMH-1 Chemical Structure
    1/16
  • 1/16

    DMH-1 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2024 Apr 16:e13646. [Abstract]

    Customer Validation
     DMH-1 (5 mg/kg; i.p.; every other day for 3 weeks ). Hepatic expression levels of ID1, OPN, and SSTR2 in Tgm2CreERT2‐R26T/Gf/f mouse liver (n ≥ 4/group).

  • 1/16

    DMH-1 purchased from MedChemExpress. Usage Cited in: J Genet Genomics. 2022 Dec;49(12):1101-1113. [Abstract]

    Customer Validation
     The mitigation effect of Bmp inhibitor DMH1(5 mM; 2 days) on the hepatized intestine phenotype is dosage dependent. Left, representative WISH images; right, the intestine versus liver ratio of the fabp10a signals in cdx1bzju1/zju1. Embryos were treated with inhibitors starting from 36 hpf, respectively, and were subjected to WISH at 5 dpf with the fabp10a probe. Each spot represented one embryo.

  • 1/16

    DMH-1 purchased from MedChemExpress. Usage Cited in: Technical University of Munich. 2015 Jun.

    Customer Validation
     Western blot analysis of MPC cells treated with DMH1. MPC cells are treated with DMH1 (3 μM or 5 μM) or with DMSO vehicle for 48 h. Proteins are then collected and probed for the expression of integrin β1, P-Smad1/5/8, P-S6 (1:500) and α-Tubulin is used as a loading control. Numbers below AKT and S6 represent the quantification of band intensities of P-AKT to AKT (OD P-AKT/ AKT) and P-S6 to S6 (OD PS6/S6) to determine the activity of the proteins.

  • DMH-1