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製品番号: HY-U00180

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KF21213

KF21213 is a highly selective ligand for mapping CNS adenosine A_2A receptors. KF21213 shows a high affinity for the adenosine A_2A receptors (K_i=3.0 nM).

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CAS 番号: 155271-17-3
分子式: C₁₉H₂₂N₄O₃
分子量:354.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

KF21213 構造式

CAS 番号: 155271-17-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

KF21213 is a highly selective ligand for mapping CNS adenosine A_2A receptors. KF21213 shows a high affinity for the adenosine A_2A receptors (K_i=3.0 nM).

IC₅₀ & Target

Ki: 3.0 nM (A_2A receptor)^[1]

Adenosine Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

[¹¹C]KF21213 as a PET ligand for mapping adenosine A_2A receptors in the central nervous system (CNS). KF21213 shows a high affinity for the adenosine A_2A receptors in vitro (K_i=3.0 nM) and a very low affinity for the A₁ receptors (K_i>10,000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

The uptake of [¹¹C]KF21213 by the striatum gradually increases for the first 15 min and then decreases. The uptake by the cortex and cerebellum is rapidly decreased after injection. Their levels are compatible with that in the blood. Consequently, the uptake ratios of striatum to cortex and striatum to cerebellum increases up to 8.6±1.6 and 10.5±2.1 (N=4), respectively, by 60 min. The striatal activity level of [¹¹C]KF21213 is retained for the initial 5 min and then gradually decreased with time, whereas that of [¹¹C]KF18446 rapidly decreases.The cerebellar activity of the two ligands rapidly decreases.The striatum-to-cerebellum uptake ratio for [¹¹C]KF21213 gradually increases to 2.4 6 0.5 (N 5 3) by 50-60 min, whereas that for [¹¹C]KF18446 increases for the first 10 min and remains constant (1.4±0.3, N=3, at 25-35 min)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 155271-17-3
分子量 354.40
分子式 C₁₉H₂₂N₄O₃
SMILES

O=C(N1C)N(C)C2=C(N(C)C(/C=C/C3=CC=C(OC)C(C)=C3C)=N2)C1=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang WF, et al. Carbon-11-labeled KF21213: a highly selective ligand for mapping CNS adenosine A(2A) receptors with positron emission tomography. Nucl Med Biol. 2000 Aug;27(6):541-6. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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