Lexacalcitol
Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 131875-08-6
- 分子式: C29H48O4
- 分子量:460.69
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保管条件:
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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CalcifediolVDR Ligand -
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DoxercalciferolVD/VDR Activator -
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ParicalcitolVitamin D Receptor Agonist -
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EldecalcitolVitamin D Analogue -
HY-32341
SeocalcitolVitamin D Agonist -
HY-32342
FalecalcitriolVD/VDR Activator -
HY-32339
MaxacalcitolVDR Agonist
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | ED50 |
0.27 nM
Compound: 3 (KH-1060)
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In vitro activity on human breast adenocarcinoma cell line MCF-7 proliferation
In vitro activity on human breast adenocarcinoma cell line MCF-7 proliferation
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[PMID: 11000014] |
体外実験
Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female spontaneously diabetic NOD mice[2]
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Dosage:0.5 mg/kg/2 days
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Administration:Intraperitoneal injection
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Result:Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.
化学情報
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CAS 番号 131875-08-6
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性状 Solid
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分子量 460.69
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分子式 C29H48O4
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Color White to off-white
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SMILES
C[C@]1(CCC/2)[C@](CC[C@@H]1[C@@H](C)OCCCC(CC)(CC)O)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C
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別名
KH1060
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42(8):1569-75. [Content Brief]
[2]. C Gysemans, et al. A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33(3):2365. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lexacalcitol 関連分類
HY-32340 関連分類
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