MRS 2578
Based on 13 publication(s) in Google Scholar
MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.50%
- CAS 番号: 711019-86-2
- 分子式: C20H20N6S4
- 分子量:472.67
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 MRS 2578
More- Phytomedicine. 2024 Jul 25:130:155754. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
- Cancer Immunol Res. 2020 Dec;17(12):1269-1271. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- CNS Neurosci Ther. 2022 Jun;28(6):851-861. [Abstract]
- Cell Oncol (Dordr). 2026 Jun 6. [Abstract]
- Int Immunopharmacol. 2025 Sep 6:165:115494. [Abstract]
- Int Immunopharmacol. 2022 Aug:109:108909. [Abstract]
- Mol Neurobiol. 2025 Jun;62(6):7054-7074. [Abstract]
- Am J Physiol Cell Physiol. 2023 Nov 1;325(5):C1228-C1243. [Abstract]
- Pharmacol Biochem Behav. 2025 Dec:257:174114. [Abstract]
- Research Square Preprint. 2020 Aug.
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P2Y Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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P2Y6 Receptor |
MRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFα-induced apoptosis in 1321N1 astrocytoma cells[1].
MRS 2578 (10 μM) completely abolishes TNF-α induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-α–induced proinflammatory gene expression in HMEC-1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old male C57BL/6J mice[4]
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Dosage:3 mg/kg
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Administration:Intraperitoneal injection; daily for 3 days after TAC
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Result:Significantly suppressed pressure overload-induced collagen deposition.
化学情報
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CAS 番号 711019-86-2
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性状 Solid
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分子量 472.67
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分子式 C20H20N6S4
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Color White to off-white
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SMILES
S=C(NCCCCNC(NC1=CC(N=C=S)=CC=C1)=S)NC2=CC(N=C=S)=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Astilbin inhibited neutrophil extracellular traps in gouty arthritis through suppression of purinergic P2Y6 receptor. [Abstract]2024 Jul 25:130:155754. PMID: 38820662
MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]
MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) showed that relief occurred and reversed the swelling caused by MSU in GA mice.
MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]
MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) improved inflammation and damage in ankle joints in GA mice.
MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]
MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) reversed MSU induced the increased of the levels of IL-1β, TNF-α, and IL-6 in GA mice.
MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]
MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) reduced the expression of protein P2Y6R and CXCR2 stimulated by MSU in ankle joints of GA mice.
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Free Radic Biol Med
P2Y6 receptor blockade promotes depression-like symptoms through oxidative stress and impaired autophagy. [Abstract]2025 Oct 17:242:203-219. PMID: 41110517
MRS 2578 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
MRS 2578 (5 mg/kg; IP) exhibited robust depressive-like behaviors, including reduced sucrose preference (anhedonia), increased immobility in the tail suspension test (behavioral despair), and decreased locomotor activity and exploratory behavior in the open field test.
MRS 2578 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
MRS 2578 (5 mg/kg; IP) significantly reduced the phosphorylation of IP3, PKC, CaMKII, calcineurin, TFEB, and NFAT2, while calreticulin levels increased in the hippocampus of mice.
MRS 2578 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
MRS 2578 (5 mg/kg; IP) significantly reduced hippocampal NeuN expression of the hippocampus.
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Cancer Immunol Res
The UDP/P2y6 axis promotes lung metastasis of melanoma by remodeling the premetastatic niche. [Abstract]2020 Dec;17(12):1269-1271. PMID: 32144377 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
CNS Neurosci Ther
Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress. [Abstract]2022 Jun;28(6):851-861. PMID: 35349212 -
Cell Oncol (Dordr)
P2RY6+ tumor-associated macrophages as a therapeutic target: suppressing tumor growth and enhancing chemosensitivity in triple-negative breast cancer. [Abstract]2026 Jun 6. PMID: 42250059 -
Int Immunopharmacol
The immunoregulator β-glucan produces antidepressant effects through microglia-mobilized astrocytic P2Y1R-BDNF signaling in the dentate gyrus. [Abstract]2025 Sep 6:165:115494. PMID: 40915186 -
Int Immunopharmacol
Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice. [Abstract]2022 Aug:109:108909. PMID: 35700583 -
Mol Neurobiol
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury. [Abstract]2025 Jun;62(6):7054-7074. PMID: 39607640 -
Am J Physiol Cell Physiol
2023 Nov 1;325(5):C1228-C1243. PMID: 37721000 -
Pharmacol Biochem Behav
Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus. [Abstract]2025 Dec:257:174114. PMID: 41106438 -
溶剤 & 溶解度
DMSO : 50 mg/mL (105.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (644 KB)
- English - EN (644 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770. [Content Brief]
[2]. Nishida M, et al. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiacfibrosis. EMBO J. 2008 Dec 3;27(23):3104-15. [Content Brief]
[3]. Riegel AK, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood, 2011, 117(8), 2548-2555. [Content Brief]
[4]. Vieira RP, et al. Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med, 2011, 184(2), 215-223. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1156 mL | 10.5782 mL | 21.1564 mL | 52.8910 mL |
| 5 mM | 0.4231 mL | 2.1156 mL | 4.2313 mL | 10.5782 mL | |
| 10 mM | 0.2116 mL | 1.0578 mL | 2.1156 mL | 5.2891 mL | |
| 15 mM | 0.1410 mL | 0.7052 mL | 1.4104 mL | 3.5261 mL | |
| 20 mM | 0.1058 mL | 0.5289 mL | 1.0578 mL | 2.6446 mL | |
| 25 mM | 0.0846 mL | 0.4231 mL | 0.8463 mL | 2.1156 mL | |
| 30 mM | 0.0705 mL | 0.3526 mL | 0.7052 mL | 1.7630 mL | |
| 40 mM | 0.0529 mL | 0.2645 mL | 0.5289 mL | 1.3223 mL | |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4231 mL | 1.0578 mL | |
| 60 mM | 0.0353 mL | 0.1763 mL | 0.3526 mL | 0.8815 mL | |
| 80 mM | 0.0264 mL | 0.1322 mL | 0.2645 mL | 0.6611 mL | |
| 100 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.5289 mL |
MRS 2578 関連分類
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