SLV-2436
Based on 1 Customer Validation
SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.03%
- CAS 番号: 2095704-43-9
- 分子式: C19H15ClN4O
- 分子量:350.80
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
MNK2 5.4 nM (IC50) |
MNK1 10.8 nM (IC50) |
体外実験
To confirm the kinome selectivity of SLV-2436 (SEL201), the broad KINOMEscan competitive binding assay is performed at 1 μM, which includes 450 distinct kinases. The observed binding profile for SLV-2436 is significantly concentrated in the CAMK family of kinases that comprises MNK1 and MNK2. SLV-2436-treated KIT-mutant melanoma cells have lower oncogenicity and reduced metastatic ability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2095704-43-9
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性状 Solid
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分子量 350.80
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分子式 C19H15ClN4O
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Color Light brown to brown
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SMILES
O=C1C=CC(C2=CC3=C(C=C2)C(N)=NN3)=CN1CC4=CC=CC(Cl)=C4
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別名
SEL201-88; SEL-201
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (285.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8506 mL | 14.2531 mL | 28.5063 mL | 71.2657 mL |
| 5 mM | 0.5701 mL | 2.8506 mL | 5.7013 mL | 14.2531 mL | |
| 10 mM | 0.2851 mL | 1.4253 mL | 2.8506 mL | 7.1266 mL | |
| 15 mM | 0.1900 mL | 0.9502 mL | 1.9004 mL | 4.7510 mL | |
| 20 mM | 0.1425 mL | 0.7127 mL | 1.4253 mL | 3.5633 mL | |
| 25 mM | 0.1140 mL | 0.5701 mL | 1.1403 mL | 2.8506 mL | |
| 30 mM | 0.0950 mL | 0.4751 mL | 0.9502 mL | 2.3755 mL | |
| 40 mM | 0.0713 mL | 0.3563 mL | 0.7127 mL | 1.7816 mL | |
| 50 mM | 0.0570 mL | 0.2851 mL | 0.5701 mL | 1.4253 mL | |
| 60 mM | 0.0475 mL | 0.2376 mL | 0.4751 mL | 1.1878 mL | |
| 80 mM | 0.0356 mL | 0.1782 mL | 0.3563 mL | 0.8908 mL | |
| 100 mM | 0.0285 mL | 0.1425 mL | 0.2851 mL | 0.7127 mL |
SLV-2436 関連分類
HY-112113 関連分類
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