Salicylanilide
Based on 5 publication(s) in Google Scholar
Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.14%
- CAS 番号: 87-17-2
- 分子式: C13H11NO2
- 分子量:213.23
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Salicylanilide
More
生物活性
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HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>100 μM
Compound: 16
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
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[PMID: 30392371] |
| HepG2 | IC50 |
89.8 μM
Compound: SAL-5
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 24953953] |
Some Salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which can be potentially afflicted by Salicylanilides on the level of two enzymes-NS3 protease and NS5B RNA polymerase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 87-17-2
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性状 Solid
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分子量 213.23
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分子式 C13H11NO2
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Color Light brown to brown
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SMILES
O=C(NC1=CC=CC=C1)C2=CC=CC=C2O
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別名
Salicylanilide; 2-Hydroxybenzanilide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744 -
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溶剤 & 溶解度
DMSO : 170 mg/mL (797.26 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6898 mL | 23.4489 mL | 46.8977 mL | 117.2443 mL |
| 5 mM | 0.9380 mL | 4.6898 mL | 9.3795 mL | 23.4489 mL | |
| 10 mM | 0.4690 mL | 2.3449 mL | 4.6898 mL | 11.7244 mL | |
| 15 mM | 0.3127 mL | 1.5633 mL | 3.1265 mL | 7.8163 mL | |
| 20 mM | 0.2345 mL | 1.1724 mL | 2.3449 mL | 5.8622 mL | |
| 25 mM | 0.1876 mL | 0.9380 mL | 1.8759 mL | 4.6898 mL | |
| 30 mM | 0.1563 mL | 0.7816 mL | 1.5633 mL | 3.9081 mL | |
| 40 mM | 0.1172 mL | 0.5862 mL | 1.1724 mL | 2.9311 mL | |
| 50 mM | 0.0938 mL | 0.4690 mL | 0.9380 mL | 2.3449 mL | |
| 60 mM | 0.0782 mL | 0.3908 mL | 0.7816 mL | 1.9541 mL | |
| 80 mM | 0.0586 mL | 0.2931 mL | 0.5862 mL | 1.4656 mL | |
| 100 mM | 0.0469 mL | 0.2345 mL | 0.4690 mL | 1.1724 mL |
Salicylanilide 関連分類
HY-B1408 関連分類
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