Sisomicin (sulfate)
Based on 5 publication(s) in Google Scholar
Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.
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- 純度: 99.29%
- CAS 番号: 53179-09-2
- 分子式: C19H37N5O7 . 5/2 H2SO4
- 分子量:692.72
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Sisomicin sulfate
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生物活性
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Aminoglycoside |
Sisomicin sulfate (6.25 μg/mL) completely inhibits the growth of various clinical isolates bacterial, such as Klebsiella, Salmonella, Citrobacter, and Staphylococcus aureus[1].
Sisomicin sulfate (20 μg/mL; 30 min) has insignificant impairment on polymorphonuclear neutrophil (PMN)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 53179-09-2
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性状 Solid
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分子量 692.72
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分子式 C19H37N5O7 . 5/2 H2SO4
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Color White to off-white
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SMILES
N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H]2O)([H])OC(CN)=CC1.[2.5H2SO4]
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別名
シソマイシン 硫酸塩
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Structure Classification
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Initial Source
Micromonospora inyoensis
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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ACS Biomater Sci Eng
pH- and Matrix Metalloproteinase-Responsive Multifunctional Bilayer Microneedles Platform for Treatment of Tinea Pedis. [Abstract]2024 May 13;10(5):3108-3119. PMID: 38659287 -
ACS Infect Dis
Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus. [Abstract]2024 Apr 12;10(4):1327-1338. PMID: 38567846 -
Curr Microbiol
Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa. [Abstract]2021 Dec 14;79(1):12. PMID: 34905092 -
STAR Protoc
Protocol for in vivo elimination of avian auditory hair cells, multiplexed mRNA detection, immunohistochemistry, and S-phase labeling. [Abstract]2024 Jun 7;5(2):103118. PMID: 38852155 -
Res Sq
2024 Apr 1:rs.3.rs-4096027. PMID: 38645253
溶剤 & 溶解度
H2O : 125 mg/mL (180.45 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (144.36 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (278 KB)
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SDS (420 KB)
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- Français - FR (420 KB)
- Deutsch - DE (420 KB)
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- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. P Noone, et al. Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use. Drugs. 1984 Jun;27(6):548-78. [Content Brief]
[2]. Crowe CC, et al. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973 Jan;3(1):24-8. [Content Brief]
[3]. Le Moli S, et al. In vitro and in vivo effect of sisomicin and gentamycin on polymorphonuclear chemotaxis and phagocytosis. Int J Immunopharmacol. 1983;5(1):49-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4436 mL | 7.2179 mL | 14.4358 mL | 36.0896 mL |
| 5 mM | 0.2887 mL | 1.4436 mL | 2.8872 mL | 7.2179 mL | |
| 10 mM | 0.1444 mL | 0.7218 mL | 1.4436 mL | 3.6090 mL | |
| 15 mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 2.4060 mL | |
| 20 mM | 0.0722 mL | 0.3609 mL | 0.7218 mL | 1.8045 mL | |
| 25 mM | 0.0577 mL | 0.2887 mL | 0.5774 mL | 1.4436 mL | |
| 30 mM | 0.0481 mL | 0.2406 mL | 0.4812 mL | 1.2030 mL | |
| 40 mM | 0.0361 mL | 0.1804 mL | 0.3609 mL | 0.9022 mL | |
| 50 mM | 0.0289 mL | 0.1444 mL | 0.2887 mL | 0.7218 mL | |
| 60 mM | 0.0241 mL | 0.1203 mL | 0.2406 mL | 0.6015 mL | |
| 80 mM | 0.0180 mL | 0.0902 mL | 0.1804 mL | 0.4511 mL | |
| 100 mM | 0.0144 mL | 0.0722 mL | 0.1444 mL | 0.3609 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sisomicin sulfate 関連分類
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