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Subasumstat

(別名: TAK-981)
34 Cited Publications
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Based on 34 publication(s) in Google Scholar

Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.

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  • 純度: 98.38%
  • CAS 番号: 1858276-04-6
  • 分子式: C25H28ClN5O5S2
  • 分子量:578.10
  • 保管条件:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Subasumstat Chemical Structure
    Subasumstat 構造式
  • Experimental Validation Results for Subasumstat
  • Experimental Validation Results for Subasumstat
  • Experimental Validation Results for Subasumstat
  • Experimental Validation Results for Subasumstat
  • Experimental Validation Results for Subasumstat
CAS 番号: 1858276-04-6
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[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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MedChemExpress（MCE）の使用を引用している文献 Subasumstat

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WBIn Vivo Efficacy StudyCell Migration/Invasion AssayRT-PCRCell Proliferation/Viability Assay
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  • In Vivo Efficacy Study
  • Cell Migration/Invasion Assay
  • Cell Proliferation/Viability Assay
  • RT-PCR
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  • Subasumstat Chemical Structure
    Subasumstat Chemical Structure
    1/16
  • 1/16

    Subasumstat purchased from MedChemExpress. Usage Cited in: iScience. 2024 Oct 11;27(11):111133. [Abstract]

    Customer Validation
     Leader and follower cells treated with indicated doses of TAK-981 for 72 h were evaluated for YAP and TAZ.

  • 1/16

    Subasumstat purchased from MedChemExpress. Usage Cited in: iScience. 2024 Oct 11;27(11):111133. [Abstract]

    Customer Validation
     Mice were treated with vehicle or 25 mg/kg TAK-981 thrice weekly. Bright-field images of tumors isolated from vehicle- and TAK-981-treated mice were captured.

  • 1/16

    Subasumstat purchased from MedChemExpress. Usage Cited in: iScience. 2024 Oct 11;27(11):111133. [Abstract]

    Customer Validation
     Spheroids generated with leader cells, follower cells, or mixes of 90% follower cells and 10% leader cells (L:F, 1:9) treated with either DMSO or 250 nM TAK-981 (72 h) were evaluated for invasive area with quantification of invasive area.

  • 1/16

    Subasumstat purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 21;14(2):147. [Abstract]

    Customer Validation
     Subasumstat (TAK-981; 25 mg/kg; every 3 days for 21 days) suppresses the growth of glioblastoma in mice.

  • 1/16

    Subasumstat purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2022 Dec;7(12):2101-2113. [Abstract]

    Customer Validation
     Subasumstat (TAK-981) boosts NLuc expression from unintegrated HIV-1 DNA, reaching a plateau at ~75 nM. Subasumstat is added to CEM-SS Cas9 and ΔSMC5 cells infected with NL-NLuc at 0, 5, 15, 30, 75, 150, 500 and 1,000 nM concentrations, and the cells are collected for an NLuc assay after 2 dpi.

  • Subasumstat