TAT
Based on 1 Customer Validation
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.92%
- CAS 番号: 191936-91-1
- 分子式: C64H118N32O14
- 分子量:1559.83
-
保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
HIV-1 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: p-02
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
|
[PMID: 35452935] |
| BEAS-2B | IC50 |
>100 μM
Compound: p-02
|
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
|
[PMID: 35452935] |
| HepG2 | IC50 |
>100 μM
Compound: p-02
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
|
[PMID: 35452935] |
| L02 | IC50 |
>100 μM
Compound: p-02
|
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by CCK-8 assay
|
[PMID: 35452935] |
TAT (YGRKKRRQRRR) represents amino acids 47-57 of the human immunodeficiency virus type I (HIV-1) TAT protein. The positively charged protein transduction domain of the HIV-1 TAT protein (TAT-PTD; residues 47-57 of TAT) rapidly translocates across the plasma membrane of living cells. TAT can cross the hydrophobic lipid bilayer of a cell membrane simply by passive diffusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 191936-91-1
-
性状 Solid
-
分子量 1559.83
-
分子式 C64H118N32O14
-
Color White to off-white
-
別名
TAT(47-57); HIV-1 TAT protein (47-57)
-
配列
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
-
シーケンスの短縮
YGRKKRRQRRR
-
Structure Classification
-
Initial Source
HIV-1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : ≥ 50 mg/mL (32.05 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6411 mL | 3.2055 mL | 6.4110 mL | 16.0274 mL |
| 5 mM | 0.1282 mL | 0.6411 mL | 1.2822 mL | 3.2055 mL | |
| 10 mM | 0.0641 mL | 0.3205 mL | 0.6411 mL | 1.6027 mL | |
| 15 mM | 0.0427 mL | 0.2137 mL | 0.4274 mL | 1.0685 mL | |
| 20 mM | 0.0321 mL | 0.1603 mL | 0.3205 mL | 0.8014 mL | |
| 25 mM | 0.0256 mL | 0.1282 mL | 0.2564 mL | 0.6411 mL | |
| 30 mM | 0.0214 mL | 0.1068 mL | 0.2137 mL | 0.5342 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
TAT 関連分類
HY-P0281 関連分類
Powered by Bioz