ZSET-845
ZSET-845 is a cognitive enhancer which enhances choline acetyltransferase activity in the hippocampus in the rat.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 324077-62-5
- 分子式: C21H18N2O
- 分子量:314.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Choline acetyltransferase[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 324077-62-5
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分子量 314.38
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分子式 C21H18N2O
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SMILES
O=C1N=C2C=CC=CN2C1(CC3=CC=CC=C3)CC4=CC=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
Rats: The passive avoidance apparatus consists of a small illuminated chamber and a larger dark chamber. The two chambers are separated by a guillotine door. On the first and second days of testing, each rat is placed in the apparatus and left for 3 min to habituate to the apparatus. On the third day, an acquisition trial is performed. Oral administration of ZSET-845 (0.001, 0.01, 0.1 or 1 mg/kg), donepezil or tacrine (0.01, 0.1, 1 or 10 mg/kg) is given 60 min before the acquisition trial. Scopolamine (2 mg/kg) is intraperitoneally (i.p.) injected 20 min before the acquisition trial. Matched control rats received vehicle only[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
参考文献
[1]. Yamaguchi Y, et al. Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat. Jpn J Pharmacol. 2001 Nov;87(3):240-4. [Content Brief]
[2]. Yamaguchi Y, et al. Antiamnesic effects of azaindolizinone derivative ZSET845 on impaired learning and decreased ChAT activity induced by amyloid-beta 25-35 in the rat. Brain Res. 2002 Aug 2;945(2):259-65. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ZSET-845 関連分類
HY-U00114 関連分類
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