AB12-82
AB12-82 is a selective dopamine receptor agonist with a Ki value of 1.88 nM for human D3R. AB12-82 achieves subtype-selective D3R activation by enhancing interactions with the D3R H291·32 residue. AB12-82 can be used in the research of nervous system-related diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H33N5O3
- 分子量:463.57
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Dopamine Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
Human D3 Receptor 1.88 nM (Ki) |
Human D2 Receptor 41 nM (Ki) |
AB12-82 (compound 6d) binds to hD3R with a Ki value of 1.88 nM, and exhibits a 21.8-fold binding selectivity over hD2L R (it binds to hD2R with a Ki value of 41 nM)[1].
AB12-82 acts as a partial agonist of hD3R, with a pEC50 of 11.76 (0.00174 nM) and an efficacy of 84.57%. Its potency for hD3R is >575000-fold more selective than that for hD2R[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
分子量 463.57
-
分子式 C26H33N5O3
-
SMILES
NC1=CC=C(C=N1)[C@H]2CN([C@H](CO2)C)CC3C(CCNC(C4=CC5=C(N4)C=CC(OC)=C5)=O)C3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AB12-82 関連分類
HY-184590 関連分類
Powered by Bioz