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AC-4-130

8 Cited Publications
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Based on 8 publication(s) in Google Scholar

AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML).

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  • 純度: 99.93%
  • CAS 番号: 1834571-82-2
  • 分子式: C37H36ClF5N2O5S
  • 分子量:751.20
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • AC-4-130 Chemical Structure
    AC-4-130 構造式
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
CAS 番号: 1834571-82-2
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  • AC-4-130 Chemical Structure
    AC-4-130 Chemical Structure
    1/16
  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Sep 1. [Abstract]

    Customer Validation
     HEK-BlueTM IL-2 cells were transfected with STATeLight5A and incubated with indicated STAT5 inhibitors (10 μM AC-4-130) for 2 hours. Subsequently, cells were stimulated with 3.5 µg of IL-2 for 30 min. mNG fluorescence lifetime was measured.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Dec:210:107499. [Abstract]

    Customer Validation
     Ten⁶ MFC cells were subcutaneously injected into 615 mice (n=6 per group), followed by intraperitoneal injection of AC-4-130 (25 mg/kg), anti-PD-1 (10 mg/kg), or AC-4-130 + anti-mPD-1, for a total of 5 treatment cycles, each lasting 21 days (AC-4-130 administered daily, anti-PD-1 administered every 4 days). Ki67 staining was performed on the subcutaneous gastric cancer model.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2023 Aug;4(8):1193-1209. [Abstract]

    Customer Validation
     HSCs were sorted from 10–13-week-old WT mice and cultured for 16 h with STAT1 (NSC 118218 phosphate, 10 µM), STAT3 (BP-1-102, 5 µM) or STAT5 (AC-4-130, 5 µM) inhibitor, or vehicle.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2022 Oct 25;18(10):e1010913. [Abstract]

    Customer Validation
     Splenic leukocytes were stimulated with recombinant IL-2 for 12 hours in the presence of the STAT5 inhibitor AC-4-130 (5 mM). The expression levels of the molecules were detected by Western blotting.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2022 Oct 25;18(10):e1010913. [Abstract]

    Customer Validation
     Splenic leukocytes were stimulated with recombinant IL-2 for 12 hours in the presence of the STAT5 inhibitor AC-4-130 (5 mM). The expression levels of the molecules were detected by qPCR.

  • AC-4-130