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United States

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製品番号: HY-184909

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AI10-a2

AI10-a2 is a tyrosinase (tyrosinase) inhibitor, with IC₅₀ values of 0.92 μM against mushroom tyrosinase using L-DOPA (HY-N0304) as the substrate and 0.68 μM using L-Tyrosine (HY-N0473) as the substrate. AI10-a2 inhibits intracellular melanin (melanin) production and reduces head pigmentation in zebrafish embryos. AI10-a2 can be used for the research of hyperpigmentation disorders.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₉H₂₃N₃O₃
分子量:341.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AI10-a2 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

AI10-a2 (12.5-100 μM) inhibits melanogenesis in B16F10 cells stimulated by Melanotan (MT)-II (HY-P0267) in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

AI10-a2 (30-60 μM; immersion; continuous; 45 hours) exhibits measurable in vivo antimelanogenic activity in zebrafish embryos at 60 μM, with a depigmentation efficacy of 12.68%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type AB strain (embryos at 6 h postfertilization)^[1]
Dosage:

30 μM; 60 μM
Administration:

immersion; continuous; 45 h
Result:

Achieved a depigmentation efficacy of 12.68% at 60 μM.
Showed minimal to negligible toxicity in treated embryos.

化学情報

分子量 341.40
分子式 C₁₉H₂₃N₃O₃
SMILES

CC1=CC(C(N2CCN(CC2)CC3=CC=C(C=C3O)O)=O)=CC(C)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pizzorno J, et al. Health Medicine. Integrative medicine (Encinitas, Calif.). 2022 Dec;21(6):8-14. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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