ALRT1550
ALRT1550 (LGD1550) is a selective retinoic acid receptor (RAR) agonist that binds RARs with exceptional potency, with Kd values of approximately 1-4 nM. ALRT1550 exhibits anti-proliferative activity, with an IC50 value of 0.22 nM in UMSCC-22B squamous carcinoma cells. In a mouse tumor xenograft model, ALRT1550 inhibited tumor growth in a dose-dependent manner, achieving a maximum inhibition rate of 89%. ALRT1550 is applicable for research in the field of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 178600-20-9
- 分子式: C23H32O2
- 分子量:340.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
134 nM
Compound: LG100567
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Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha
Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha
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[PMID: 8709094] |
| CV-1 | EC50 |
77 nM
Compound: LG100567
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Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma
Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma
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[PMID: 8709094] |
| CV-1 | EC50 |
87 nM
Compound: LG100567
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Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta
Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta
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[PMID: 8709094] |
| ME-180 | IC50 |
1 nM
Compound: 5; ALRT1550
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Antiproliferative activity against human ME-180 cells assessed as inhibition of cell growth by [3H]-thymidine incorporation based liquid scintillation counter analysis
Antiproliferative activity against human ME-180 cells assessed as inhibition of cell growth by [3H]-thymidine incorporation based liquid scintillation counter analysis
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[PMID: 33895500] |
化学情報
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CAS 番号 178600-20-9
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分子量 340.50
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分子式 C23H32O2
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SMILES
OC(/C=C(C)/C=C/C=C(C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1)\C)=O
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別名
LGD1550
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Shalinsky DR, et al. A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. Cancer Res. 1997 Jan 1;57(1):162-8. [Content Brief]
[2]. Zhang L, et al. Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. J Med Chem. 1996 Jul 5;39(14):2659-63. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ALRT1550 関連分類
HY-106963 関連分類
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