Amdoxovir
Amdoxovir (DAPD) is an orally active nucleoside reverse transcriptase inhibitor. Amdoxovir is active against wild-type and NRTl-resistant viruses. Amdoxovir is the prodrug of dioxolane guanosine. Amdoxovir can be used for research of HIV/AIDS.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 145514-04-1
- 分子式: C9H12N6O3
- 分子量:252.23
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | CC50 |
>100 μM
Compound: DAPD, AMDX
|
Cytotoxicity against human CEM cells after 2 to 4 days by MTT assay
Cytotoxicity against human CEM cells after 2 to 4 days by MTT assay
|
[PMID: 24015326] |
| CCRF-CEM | CC50 |
>100 μM
Compound: 1, DAPD
|
Cytotoxicity against human CEM cell
Cytotoxicity against human CEM cell
|
[PMID: 25458500] |
| HepG2 | CC50 |
>100 μM
Compound: DAPD, AMDX
|
Cytotoxicity against human HepG2 cells after 2 to 4 days by neutral red dye uptake assay
Cytotoxicity against human HepG2 cells after 2 to 4 days by neutral red dye uptake assay
|
[PMID: 24015326] |
| HepG2 | CC50 |
>100 μM
Compound: 1, DAPD
|
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
|
[PMID: 25458500] |
| Huh-7 | CC50 |
>100 μM
Compound: DAPD, AMDX
|
Cytotoxicity against human HuH7 cells after 2 to 4 days by MTT assay
Cytotoxicity against human HuH7 cells after 2 to 4 days by MTT assay
|
[PMID: 24015326] |
| PBMC | CC50 |
>100 μM
Compound: DAPD, AMDX
|
Cytotoxicity against human PBMC after 2 to 4 days by MTT assay
Cytotoxicity against human PBMC after 2 to 4 days by MTT assay
|
[PMID: 24015326] |
| PBMC | CC50 |
>100 μM
Compound: 1, DAPD
|
Cytotoxicity against human PBMC
Cytotoxicity against human PBMC
|
[PMID: 25458500] |
| Vero | CC50 |
>100 μM
Compound: DAPD, AMDX
|
Cytotoxicity against African green monkey Vero cells after 2 to 4 days by MTT assay
Cytotoxicity against African green monkey Vero cells after 2 to 4 days by MTT assay
|
[PMID: 24015326] |
| Vero | CC50 |
>100 μM
Compound: 1, DAPD
|
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
|
[PMID: 25458500] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 145514-04-1
-
分子量 252.23
-
分子式 C9H12N6O3
-
SMILES
NC1=C2C(N([C@@H]3O[C@@H](OC3)CO)C=N2)=NC(N)=N1
-
別名
DAPD
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)