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製品番号: HY-N21536

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Angustone A

Name: Angustone A
Brand: MedChemExpress
SKU: HY-N21536
Availability: PreOrder

(別名: 2'-Hydroxylupalbigenin)

Angustone A (2'-Hydroxylupalbigenin) is a diisoprenylated isoflavone with insect feeding inhibitory activity and moderate antifungal activity. Angustone A can be converted into various phenolic metabolites by Aspergillus flavus through modification of the isoprenyl side chains at the C-6 and C-3' positions. Angustone A can be used in studies on antifungal properties of natural products, insect feeding behavior, fungal biotransformation, and anticancer activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 90686-13-8
分子式: C₂₅H₂₆O₆
分子量:422.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Angustone A 構造式

CAS 番号: 90686-13-8

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生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.1 μM Compound: 19	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 26841168]
HepG2	IC₅₀	1.1 μM Compound: 19	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 26841168]
MCF7	IC₅₀	6 μM Compound: 19	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 26841168]
SW480	IC₅₀	6.4 μM Compound: 19	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 26841168]

体外実験

Angustone A (2'-Hydroxylupalbigenin) (50 μg/mL; 3 days) undergoes biotransformation by Aspergillus flavus AHU 7049 into 10 structurally distinct isoflavonoid metabolites, among which AF-d-1 (lupinisoflavone F) has the highest content (10.44 mg of product obtained from 50 mg of substrate)^[1].
Angustone A (compound Ⅵ) (40-100 μg/mL; 24 h) gradually inhibits the growth of Colletotrichum gloeosporioides spore juveniles, with an ED₉₅ of > 100 μg/mL against both C. gloeosporioides and Cladosporium cladosporioides^[2].
Angustone A (200 μg/mL; 24 h) significantly reduces the feeding response of third-instar larvae of Costelytra zealandica and Heteronychus arator, with feeding responses of 35.9% and 56.8%, respectively^[2].
Angustone A exhibits an IC₅₀ of 1.1-7.1 μM and inhibits the growth of four cancer cell lines^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Angustone A (2'-Hydroxylupalbigenin) (2-200 μg/mL; incorporated into feeding disk; 24-hour exposure) significantly reduces the feeding behavior of third-instar larvae of Costelytra zealandica at the concentration of 200 μg/mL, with a 35.9% decrease in feeding response rate^[2].
Angustone A (200 μg/mL; mixed into feeding dishes; 24 h exposure) significantly reduces the feeding behavior of third-instar Heteronychus arator larvae, with a 56.8% decrease in feeding response rate at the concentration of 200 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Field-collected third-instar larvae^[2]
Dosage:

2 μg/mL; 20 μg/mL; 100 μg/mL; 200 μg/mL
Administration:

Incorporated into feeding disk; 24-hour exposure
Result:

Resulted in a 93.9% feeding response at 2 μg/mL.
Resulted in an 85.9% feeding response at 20 μg/mL.
Resulted in a 76.2% feeding response at 100 μg/mL.
Resulted in a 35.9% feeding response at 200 μg/mL, which represented a significant reduction in feeding.

Animal Model:

Field-collected third-instar larvae^[2]
Dosage:

200 μg/mL
Administration:

Incorporated into feeding disk; 24-hour exposure
Result:

Resulted in a 56.8% feeding response, which represented a significant reduction in feeding.

化学情報

CAS 番号 90686-13-8
分子量 422.47
分子式 C₂₅H₂₆O₆
SMILES

O=C1C(C2=C(O)C(C/C=C(C)\C)=C(O)C=C2)=COC3=CC(O)=C(C/C=C(C)\C)C(O)=C13
別名

2'-Hydroxylupalbigenin
Structure Classification
- Flavonoids
- Flavones
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Nakahara S, Tahara S, Mizutani J, Ingham JL. Transformation of the Diprenylated Isoflavone 2'-Hydroxylupalbigenin by Aspergillus flavus. Agricultural and Biological Chemistry. 1986;50(4):863-873.

[2]. Lane GA, et al. Isoflavonoids as insect feeding deterrents and antifungal components from root ofLupinus angustifolius. Journal of chemical ecology. 1987 Apr;13(4):771-83.

[3]. Fan H, Xuan J, Zhang K, Jiang J. Anticancer component identification from the extract of Dysosma versipellis and Glycyrrhiza uralensis based on support vector regression and mean impact value. Analytical Methods. 2018.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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