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製品番号: HY-182546

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Anticancer agent 312

Anticancer agent 312 is a heterogeneous nuclear ribonucleoprotein A18 (hnRNP A18) inhibitor with an IC₅₀ of 2.9 μM. Anticancer agent 312 binds to the RNA recognition motif of hnRNP A18 and blocks its binding to homologous RNA transcripts. Anticancer agent 312 acts as a protein synthesis inhibitor by blocking hnRNP A18-mediated mRNA translation. Anticancer agent 312 is applicable to research on cancers such as melanoma.

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CAS 番号: 664968-32-5
分子式: C₁₈H₁₄N₂O₃S
分子量:338.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 312 構造式

CAS 番号: 664968-32-5

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

Anticancer agent 312 (Compound 5) (3 h) binds to and stabilizes hnRNP A18 in LOX-IM-VI melanoma cells, with an EC₅₀ of 23.8 μM^[1].
Anticancer agent 312 disrupts hnRNP A18-mediated transcript stability and translation in LOX-IM-VI melanoma cells, and reduces the expression of CAT protein carrying the Trx 3'UTR reporter gene^[1].
Anticancer agent 312 (0-200 μM) downregulates the protein expression of thioredoxin in LOX-IM-VI melanoma cells in a dose-dependent manner^[1].
Anticancer agent 312 (0-200 μM) downregulates CTLA-4 protein expression in PC-3 prostate cancer cells in a dose-dependent manner^[1].
Anticancer agent 312 (0-150 μM; 24 h) selectively reduces the viability of various human cancer cell lines, and exhibits moderate toxicity to normal human mammary epithelial cells at high concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 664968-32-5
分子量 338.38
分子式 C₁₈H₁₄N₂O₃S
SMILES

O=C(C1=CC=CC=C1)OC2=C(C)SC(NC(C3=CC=CC=C3)=O)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. France Carrier, et al. Protein Translation Inhibitors and Uses Thereof. US20200368208A1.

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