Anticancer agent 313
Anticancer agent 313 is a MetAP2 inhibitor with an IC50 of 4.11 μM. Anticancer agent 313 activates the transcription factor ATF4 via a non-canonical mTORC1-dependent pathway. Anticancer agent 313 inhibits cancer cell proliferation. Anticancer agent 313 is applicable to the research of breast cancer and pancreatic cancer.
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- 分子式: C18H26N2O3Si
- 分子量:346.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MetAp2 |
Anticancer agent 313 (compound 3) (72 h) inhibits the proliferation of 67nr, 4T1, MDA-MB-231, BxPC3 and MIA PaCa-2 cancer cell lines[1].
Anticancer agent 313 induces ATF4 expression in 67nr, MDA-MB-231 and MIA PaCa-2 cancer cell lines via an mTORC1-dependent non-canonical (eIF2α phosphorylation-independent) mechanism, but has no such effect in 4T1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:67nr, 4T1, MDA-MB-231, BxPC3, MIA PaCa-2 cells
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Concentration:/
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Incubation Time:72 h
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Result:Had IC50 values of 14.4 (67nr), 2.76 (4T1), 17.32 (MDA-MB-231), 16.7 (BxPC3), 9.71 (MIA PaCa-2) μM.
化学情報
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分子量 346.50
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分子式 C18H26N2O3Si
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SMILES
CC(C)[Si](C(C)C)(C(C)C)OC1=CC=C([N+]([O-])=O)C2=CC=CN=C21
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 313 関連分類
HY-182781 関連分類
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