country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-190607

Copy Link Print Information

Anticancer agent-369

Anticancer agent-369 is an anticancer agent. Anticancer agent-369 exhibits antiproliferative and cytotoxic activities against gastric cancer, hepatocellular carcinoma, and lung cancer cell lines. Anticancer agent-369 binds within the active pocket of the cell cycle phosphatase Cdc25B and forms hydrogen-bonding interactions with active site residues. Anticancer agent-369 can be used in research related to gastric cancer, liver cancer, and lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2584415-31-4
分子式: C₁₉H₁₃F₂N₇OS
分子量:425.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent-369 構造式

CAS 番号: 2584415-31-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
MGC-803	IC50	2.43 μM	Antiproliferative activity against human gastric carcinoma MGC-803 cells assessed as viability reduction by MTT assay. Antiproliferative activity against human gastric carcinoma MGC-803 cells assessed as viability reduction by MTT assay.	41967614
HepG2	IC50	1.73 μM	Antiproliferative activity against human hepatocellular carcinoma HepG2 cells assessed as viability reduction by MTT assay. Antiproliferative activity against human hepatocellular carcinoma HepG2 cells assessed as viability reduction by MTT assay.	41967614
PC-9	IC50	4.03 μM	Antiproliferative activity against human pulmonary carcinoma PC-9 cells assessed as viability reduction by MTT assay. Antiproliferative activity against human pulmonary carcinoma PC-9 cells assessed as viability reduction by MTT assay.	41967614
HUVEC	IC50	34.62 μM	Cytotoxicity against normal human umbilical vein endothelial HUVEC cells by MTT assay. Cytotoxicity against normal human umbilical vein endothelial HUVEC cells by MTT assay.	41967614

体外実験

Anti-cancerOthers

Anti-cancer

Anticancer agent-369 (compound 3h) inhibits the proliferation of MGC-803, HepG2, and PC-9 cancer cells in the MTT assay, with IC₅₀ values of 2.43, 1.73, and 4.03 μM, respectively^[1].

Others

Anticancer agent-369 shows weak cytotoxicity against normal HUVEC cells, with an IC₅₀ of 34.62 μM in the MTT assay^[1].
Anticancer agent-369, as shown by molecular docking studies, can embed into the active site of Cdc25B and form multiple hydrogen bonds with residues within this site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 2584415-31-4
分子量 425.41
分子式 C₁₉H₁₃F₂N₇OS
SMILES

O=C1N=C(NC2=C(F)C=CC=C2)C(NC3=CC=CC=C3F)=C/C1=N/NC4=NN=CS4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Long Z, et al. Synthesis and biological evaluation of novel pyridone derivatives containing 1,3,4-thiadiazol as potential anticancer agents. Bioorganic & medicinal chemistry letters. 2026 Aug;137:130654. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ