Antimalarial agent 49
Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C28H18F4N6O
- 分子量:530.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Antimalarial agent 49 (compound 15k) (0.37-10 μM, 40 h) inhibits the development of P. berghei liver stage (IC50: 5.88 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Tmax | Plasma Concentration | Vd | Clearance (CL) | AUC | MRT |
|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 100 mg/kg | p.o. | 3.74 h | 4.00 h | 15.17 ng/mL | 4.97 L/kg | 0.92 L/h/kg | 0.11 ng·h/mL | 7.30 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Swiss mice (6-8-week-old, 18 ± 2 g) were intra-peritoneally inoculated with 1x106 P.yoelii N67 infected red blood cells (iRBCs)[1]
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Dosage:100 mg/kg
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Administration:Oral gavage (p.o.), once every day for 4 d
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Result:Inhibited 42.55% of parasite growth on the 7th day and 35.93% of parasite growth on the 10th day.
Prolonged the median survival time (17 d) compared with the Chloroquine (HY-17589A) (10 mg/kg)-treated group (16 d).
化学情報
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分子量 530.48
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分子式 C28H18F4N6O
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SMILES
O=C(C1=CC2=C(C(C3=CC=C(F)C=C3)=N1)NC4=C2C=CC=C4)NCC5=CN(C6=CC=CC(C(F)(F)F)=C6)N=N5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimalarial agent 49 関連分類
HY-173312 関連分類
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