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United States

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製品番号: HY-189011

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FPPS-IN-3

FPPS-IN-3 is an FPPS inhibitor with an IC₅₀ of 7.75 µM (Leishmania major) and exhibits antimalarial activity. FPPS-IN-3 also inhibits PFK activity. FPPS-IN-3 inhibits the growth of Entamoeba histolytica and Plasmodium falciparum. FPPS-IN-3 is cytotoxic to nasopharyngeal carcinoma cells. FPPS-IN-3 can be used for research on amoebiasis and malaria.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 16610-63-2
分子式: C₁₂H₂₈O₇P₂
分子量:346.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

FPPS-IN-3 構造式

CAS 番号: 16610-63-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	LD₅₀	492 μM	Cytotoxicity against human KB nasopharyngeal carcinoma cells. Cytotoxicity against human KB nasopharyngeal carcinoma cells.	14695831

体外実験

Anti-cancerParasitic Infection

Anti-cancer

FPPS-IN-3 exhibits an LD₅₀ of 492 µM against human KB nasopharyngeal carcinoma cells^[1].

Parasitic Infection

FPPS-IN-3 (Compound 8) (0-150 µM; incubation for 90 h, followed by incubation with [³H]hypoxanthine for 6 h) inhibits the growth of Entamoeba histolytica HM-1:IMSS with an IC₅₀ of 63.7 µM^[1].
FPPS-IN-3 (48 h) inhibits the intraerythrocytic growth of P. falciparum 3D7 with an IC₅₀ of 1.07 µM^[1].
FPPS-IN-3 inhibits Leishmania major FPPS with an IC₅₀ of 7.75 µM^[1].
FPPS-IN-3 inhibits the expressed E. histolytica PPi-PFK with an IC₅₀ of 40 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

化学情報

CAS 番号 16610-63-2
分子量 346.29
分子式 C₁₂H₂₈O₇P₂
SMILES

O=P(O)(C(CCCCCCCCCCC)(P(O)(O)=O)O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ghosh S, et al. Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. Journal of medicinal chemistry. 2004 Jan 01;47(1):175-87. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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