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製品番号: HY-10364

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AP24163

AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC₅₀ values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 926922-16-9
分子式: C₂₉H₂₅F₃N₈O
分子量:558.56

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

AP24163 構造式

CAS 番号: 926922-16-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Bcr-Abl アイソフォーム固有の製品をすべて表示 :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	24 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	42 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	44 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	63 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	64 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	6455 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	7.3 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	7.3 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay	[PMID: 19572547]
K562	IC₅₀	4.3 μM Compound: 14a, AP24163	Antiproliferative activity against human K562 cells after 3 days by MTS assay Antiproliferative activity against human K562 cells after 3 days by MTS assay	[PMID: 19572547]

化学情報

CAS 番号 926922-16-9
分子量 558.56
分子式 C₂₉H₂₅F₃N₈O
SMILES

O=C(NC1=CC(N2C=NC(C)=C2)=CC(C(F)(F)F)=C1)C3=CC(/C=C/N4C5=NC=NC(NC6CC6)=C5N=C4)=C(C)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.