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製品番号: HY-10364

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AP24163

AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC₅₀ values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 926922-16-9
分子式: C₂₉H₂₅F₃N₈O
分子量:558.56

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

AP24163 構造式

CAS 番号: 926922-16-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Bcr-Abl アイソフォーム固有の製品をすべて表示 :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	24 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	42 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	44 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	63 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	64 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	6455 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	7.3 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	7.3 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay	[PMID: 19572547]
K562	IC₅₀	4.3 μM Compound: 14a, AP24163	Antiproliferative activity against human K562 cells after 3 days by MTS assay Antiproliferative activity against human K562 cells after 3 days by MTS assay	[PMID: 19572547]

化学情報

CAS 番号 926922-16-9
分子量 558.56
分子式 C₂₉H₂₅F₃N₈O
SMILES

O=C(NC1=CC(N2C=NC(C)=C2)=CC(C(F)(F)F)=C1)C3=CC(/C=C/N4C5=NC=NC(NC6CC6)=C5N=C4)=C(C)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (240 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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